Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.
about
New insights into an X-traordinary viral proteinIdentification and characterization of naturally occurring splice variants of SAMHD1How SAMHD1 changes our view of viral restrictionHow SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complexLv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to IntegrationSAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.The human antiviral factor TRIM11 is under the regulation of HIV-1 Vpr.HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells.The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5α.Antiretroviral restriction factors.Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages.Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cellsSAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferonsEvidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.Host restriction factors in retroviral infection: promises in virus-host interaction.Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection.Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supplyInnate immune sensing of HIV-1 by dendritic cells.HIV relies on neddylation for ubiquitin ligase-mediated functionsCellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells.Dendritic cell-lymphocyte cross talk downregulates host restriction factor SAMHD1 and stimulates HIV-1 replication in dendritic cellsRestricted access to myeloid cells explained.The role of HIV-1 Vpr in promoting the infection of nondividing cells and in cell cycle arrest.Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated.HIV1-viral protein R (Vpr) mutations: associated phenotypes and relevance for clinical pathologies.Degradation of SAMHD1 by Vpx Is Independent of Uncoating.Different antigen-processing activities in dendritic cells, macrophages, and monocytes lead to uneven production of HIV epitopes and affect CTL recognition.Evidence for a different susceptibility of primate lentiviruses to type I interferons.Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.Histone deacetylase inhibitors containing a benzamide functional group and a pyridyl cap are preferentially effective human immunodeficiency virus-1 latency-reversing agents in primary resting CD4+ T cells.HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3.Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes.CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5α.Vpr overcomes macrophage-specific restriction of HIV-1 Env expression and virion productionSAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells.
P2860
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P2860
Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Vpx rescues HIV-1 transduction ...... ablished by type 1 interferon.
@ast
Vpx rescues HIV-1 transduction ...... ablished by type 1 interferon.
@en
type
label
Vpx rescues HIV-1 transduction ...... ablished by type 1 interferon.
@ast
Vpx rescues HIV-1 transduction ...... ablished by type 1 interferon.
@en
prefLabel
Vpx rescues HIV-1 transduction ...... ablished by type 1 interferon.
@ast
Vpx rescues HIV-1 transduction ...... ablished by type 1 interferon.
@en
P2860
P356
P1433
P1476
Vpx rescues HIV-1 transduction ...... ablished by type 1 interferon.
@en
P2093
Christian Reinhard
P2860
P2888
P356
10.1186/1742-4690-8-49
P577
2011-06-22T00:00:00Z
P5875
P6179
1046299518