Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. - Test2 - elhamkhani - TriplyDB

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

http://www.wikidata.org/entity/Q35108463

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Glucocorticoid regulation of the circadian clock modulates glucose homeostasis The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases Enzymatic intracrine regulation of white adipose tissue Adipose tissue and adrenal glands: novel pathophysiological mechanisms and clinical applications Modulation of 11β-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammation Mutations of key hydrophobic surface residues of 11β-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)Obesity-hypertension: an ongoing pandemic.11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.Tissue-specific increases in 11beta-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women.Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis.Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets.Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog.11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.The renin angiotensin system and the metabolic syndrome Current therapies and emerging drugs in the pipeline for type 2 diabetes.The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.Cardiac remodeling in obesity.11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus.Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP.Increased whole-body and sustained liver cortisol regeneration by 11beta-hydroxysteroid dehydrogenase type 1 in obese men with type 2 diabetes provides a target for enzyme inhibition Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes.Dexamethasone promotes hypertension by allele-specific regulation of the human angiotensinogen gene Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease.G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome.Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.The role of cortisol in the pathogenesis of the metabolic syndrome Tissue-specific dysregulation of 11beta-hydroxysteroid dehydrogenase type 1 and pathogenesis of the metabolic syndrome.The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats Genetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice.Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.

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P2860

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

http://www.wikidata.org/entity/Q35108463

description

2003 nî lūn-bûn

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2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2003年の論文

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name

Transgenic amplification of gl ...... s high blood pressure in mice.

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Transgenic amplification of gl ...... s high blood pressure in mice.

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Transgenic amplification of gl ...... s high blood pressure in mice.

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Transgenic amplification of gl ...... s high blood pressure in mice.

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Transgenic amplification of gl ...... s high blood pressure in mice.

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Transgenic amplification of gl ...... s high blood pressure in mice.

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P1433

Journal of Clinical Investigation

P1476

Transgenic amplification of gl ...... s high blood pressure in mice.

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P2093

Christopher J Kenyon

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Hiroaki Masuzaki

http://www.w3.org/2001/XMLSchema#string

Hiroshi Shinyama

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Hiroshi Yamamoto

http://www.w3.org/2001/XMLSchema#string

Janice M Paterson

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Jeffrey S Flier

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Joel K Elmquist

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John J Mullins

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Jonathan R Seckl

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Matthew G F Sharp

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P2860

Obesity and insulin resistance

Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action

Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation

Obesity as a medical problem

Obesity and the regulation of energy balance

Tissue-specific dysregulation of cortisol metabolism in human obesity.

Crosstalk between insulin and angiotensin II signalling systems.

Angiotensin receptors: molecular biology and signalling.

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83-90

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10.1172/JCI17845

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1

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112

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162290

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