Systematic discovery of multicomponent therapeutics. - Test2 - elhamkhani - TriplyDB

Systematic discovery of multicomponent therapeutics.

Systematic discovery of multicomponent therapeutics.

http://www.wikidata.org/entity/Q35147474

about

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma.Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition Approaches to modernize the combination drug development paradigm High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling Prediction of drug combinations by integrating molecular and pharmacological data Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine An innovative strategy for dual inhibitor design and its application in dual inhibition of human thymidylate synthase and dihydrofolate reductase enzymes Pooled screening for synergistic interactions subject to blocking and noise ASDCD: antifungal synergistic drug combination database Synergistic and antagonistic drug combinations depend on network topology Synergistic interaction between selective drugs in cell populations models A network flow-based method to predict anticancer drug sensitivity Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling A Network-Based Target Overlap Score for Characterizing Drug Combinations: High Correlation with Cancer Clinical Trial Results Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis Network-based drug discovery by integrating systems biology and computational technologies Multicomponent therapeutics of berberine alkaloids Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.Tinnitus: network pathophysiology-network pharmacology.Systematic identification of synergistic drug pairs targeting HIV Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication.High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection.Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration.Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines.A global view of drug-therapy interactions Drug-therapy networks and the prediction of novel drug targets.Combination chemical genetics

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Systematic discovery of multicomponent therapeutics.

http://www.wikidata.org/entity/Q35147474

description

2003 nî lūn-bûn

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2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2003 թվականի հունիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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Systematic discovery of multicomponent therapeutics.

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Systematic discovery of multicomponent therapeutics.

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Systematic discovery of multicomponent therapeutics.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Systematic discovery of multicomponent therapeutics.

@en

P2093

Alexis A Borisy

http://www.w3.org/2001/XMLSchema#string

Brent R Stockwell

http://www.w3.org/2001/XMLSchema#string

Curtis T Keith

http://www.w3.org/2001/XMLSchema#string

E Roydon Price

http://www.w3.org/2001/XMLSchema#string

George Serbedzija

http://www.w3.org/2001/XMLSchema#string

Grant R Zimmermann

http://www.w3.org/2001/XMLSchema#string

Joseph Lehar

http://www.w3.org/2001/XMLSchema#string

Margaret S Lee

http://www.w3.org/2001/XMLSchema#string

Michael A Foley

http://www.w3.org/2001/XMLSchema#string

Nicole W Hurst

http://www.w3.org/2001/XMLSchema#string

P2860

The KEGG databases at GenomeNet.

Oncogenic kinase signalling

Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Systems biology: a brief overview

Paclitaxel activity, dose, and schedule: data from phase III trials in metastatic breast cancer.

Effects of psychotropic drugs on cell proliferation and differentiation.

The cell cycle and development: redundant roles of cell cycle regulators.

Genomic biology.

Mechanism-based target identification and drug discovery in cancer research.

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10.1073/PNAS.1337088100

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13

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100

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2003-06-10T00:00:00Z

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10715340

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12799470

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164698

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