Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. - Test2 - elhamkhani - TriplyDB

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

http://www.wikidata.org/entity/Q35193221

about

Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population β-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement Alpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination?Regenerative medicine in diabetes From Beta cell replacement to beta cell regeneration: implications for antidiabetic therapy Transcriptional and epigenetic regulation in human islets Control of cell identity in pancreas development and regeneration Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss Transcription factor regulation of pancreatic organogenesis, differentiation and maturation Epigenomic plasticity enables human pancreatic α to β cell reprogramming.Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells Revealing transcription factors during human pancreatic β cell development.Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas Pancreatic and Islet Development and Function: The Role of Thyroid Hormone.Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression Deconstructing pancreas developmental biology.Transgenic Expression of a Single Transcription Factor Pdx1 Induces Transdifferentiation of Pancreatic Acinar Cells to Endocrine Cells in Adult Mice.Minireview: Directed Differentiation and Encapsulation of Islet β-Cells-Recent Advances and Future Considerations.Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells.Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genes Research Resource: Genetic Labeling of Human Islet Alpha Cells.Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges.Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.Stem Cells in the Treatment of Insulin-Dependent Diabetes Mellitus.VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus.IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation.Differentiated human stem cells resemble fetal, not adult, β cells.Pdx1 maintains β cell identity and function by repressing an α cell program.Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes.

P2860

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P2860

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

http://www.wikidata.org/entity/Q35193221

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

@ast

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

@en

type

label

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

@ast

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

@en

prefLabel

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

@ast

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

@en

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P1433

Genes & Development

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Context-specific α- to-β-cell reprogramming by forced Pdx1 expression

@en

P2093

Christopher V E Wright

http://www.w3.org/2001/XMLSchema#string

Daniel F Boyer

http://www.w3.org/2001/XMLSchema#string

Fabrizio Thorel

http://www.w3.org/2001/XMLSchema#string

Yu-Ping Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes

The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6.

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1680-1685

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scholarly article

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10.1101/GAD.16875711

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16

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25

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Pedro Luis Herrera

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2011-08-01T00:00:00Z

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51581653

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21852533

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3165933

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