Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.
about
The role of naive T cell precursor frequency and recruitment in dictating immune response magnitudeTracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stagesThe same self-peptide selects conventional and regulatory CD4⁺ T cells with identical antigen receptors.Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.Optimal T-cell receptor affinity for inducing autoimmunity.In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.Cis-acting pathways selectively enforce the non-immunogenicity of shed placental antigen for maternal CD8 T cells.The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes.Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in miceBi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells.Common clonal origin of central and resident memory T cells following skin immunizationA broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.Pregnancy imprints regulatory memory that sustains anergy to fetal antigen.CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion.Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen.CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.Tolerance to noninherited maternal antigens, reproductive microchimerism and regulatory T cell memory: 60 years after 'Evidence for actively acquired tolerance to Rh antigens'.Apoptosis in response to microbial infection induces autoreactive TH17 cellsProgrammed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against AutoimmunityCutting edge: committed Th1 CD4+ T cell differentiation blocks pregnancy-induced Foxp3 expression with antigen-specific fetal loss.Flow-cytometric analysis of rare antigen-specific T cells.Foxp3⁺ T(reg) cells in humoral immunity.A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging.T-cell selection and intestinal homeostasis.TCR signal quantity and quality in CD4(+) T cell differentiation.Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute RejectionCXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiationDevelopment of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen.Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies.Relationship between CD4 Regulatory T Cells and Anergy In Vivo.Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection.Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage.Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice.
P2860
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P2860
Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Quantitative impact of thymic ...... lass II-specific CD4+ T cells.
@ast
Quantitative impact of thymic ...... lass II-specific CD4+ T cells.
@en
type
label
Quantitative impact of thymic ...... lass II-specific CD4+ T cells.
@ast
Quantitative impact of thymic ...... lass II-specific CD4+ T cells.
@en
prefLabel
Quantitative impact of thymic ...... lass II-specific CD4+ T cells.
@ast
Quantitative impact of thymic ...... lass II-specific CD4+ T cells.
@en
P2093
P2860
P356
P1476
Quantitative impact of thymic ...... lass II-specific CD4+ T cells.
@en
P2093
H Hamlet Chu
James J Moon
Jennifer L McClaren
Marc K Jenkins
Paul G Thomas
Thomas H Oguin
P2860
P304
14602-14607
P356
10.1073/PNAS.1109806108
P407
P50
P577
2011-08-22T00:00:00Z