Predicting the functional impact of protein mutations: application to cancer genomics
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Chapter 14: Cancer genome analysisMelanoma genome sequencing reveals frequent PREX2 mutationsGenome sequencing identifies a basis for everolimus sensitivityUbc13: the Lys63 ubiquitin chain building machineMultivariate Methods for Genetic Variants Selection and Risk Prediction in Cardiovascular DiseasesPractical aspects of NGS-based pathways analysis for personalized cancer science and medicineCurrent strategies for mutation detection in phenotype-driven screens utilising next generation sequencingNext-generation sequencing: hype and hope for development of personalized radiation therapy?Using large-scale genomics data to identify driver mutations in lung cancer: methods and challengesNetwork biomarkers reveal dysfunctional gene regulations during disease progressionEmerging patterns of somatic mutations in cancerLoss of function mutations in HARS cause a spectrum of inherited peripheral neuropathies.Comprehensive analysis via exome sequencing uncovers genetic etiology in autosomal recessive nonsyndromic deafness in a large multiethnic cohortA genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.Clinical and in vivo evidence that EGFR S768I mutant lung adenocarcinomas are sensitive to erlotinib.Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma.HER2 activating mutations are targets for colorectal cancer treatmentThe role of prostate tumor overexpressed 1 in cancer progressionComputational characterisation of cancer molecular profiles derived using next generation sequencingAnalysis of genetic variation and potential applications in genome-scale metabolic modelingGermline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid CancerMutations in POMGNT1 cause non-syndromic retinitis pigmentosaExome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemiaA novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestineThe cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataGenetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial Colorectal CarcinomasInvolvement of MBD4 inactivation in mismatch repair-deficient tumorigenesisComprehensive genomic characterization of squamous cell lung cancers.NEK1 variants confer susceptibility to amyotrophic lateral sclerosisIntegrative analysis of complex cancer genomics and clinical profiles using the cBioPortalUnique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancerGetting personalized cancer genome analysis into the clinic: the challenges in bioinformaticsPrioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing DataDeriving a mutation index of carcinogenicity using protein structure and protein interfacesThe structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancerComprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation SequencingGenetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum DisorderChallenges of Identifying Clinically Actionable Genetic Variants for Precision MedicineEvolution of the cancer genomeA phylomedicine approach to understanding the evolution of auditory sensory perception and disease in mammals
P2860
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P2860
Predicting the functional impact of protein mutations: application to cancer genomics
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Predicting the functional impact of protein mutations: application to cancer genomics
@ast
Predicting the functional impact of protein mutations: application to cancer genomics
@en
type
label
Predicting the functional impact of protein mutations: application to cancer genomics
@ast
Predicting the functional impact of protein mutations: application to cancer genomics
@en
prefLabel
Predicting the functional impact of protein mutations: application to cancer genomics
@ast
Predicting the functional impact of protein mutations: application to cancer genomics
@en
P2860
P356
P1476
Predicting the functional impact of protein mutations: application to cancer genomics
@en
P2093
Boris Reva
Chris Sander
P2860
P356
10.1093/NAR/GKR407
P407
P577
2011-07-03T00:00:00Z