Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques - Test2 - elhamkhani - TriplyDB

Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

http://www.wikidata.org/entity/Q35484743

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HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies Host-pathogen interaction in HIV infection Natural SIV hosts: showing AIDS the door CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model Barriers to HIV Cure.CD4+ T cells contain early extrapulmonary tuberculosis (TB) dissemination and rapid TB progression and sustain multieffector functions of CD8+ T and CD3- lymphocytes: mechanisms of CD4+ T cell immunity.Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts.Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa.T cell activation but not polyfunctionality after primary HIV infection predicts control of viral load and length of the time without therapy.Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain HIV-1-induced AIDS in monkeys Interleukin 23 produced by myeloid dendritic cells contributes to T-cell dysfunction in HIV type 1 infection by inducing SOCS1 expression Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia.The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239.Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection.Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus-Infected Rhesus Macaques May Contribute to Accumulation of TFH in Chronic Infection.Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors.Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.NK and CD4+ T cell cooperative immune responses correlate with control of disease in a macaque simian immunodeficiency virus infection model.Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth Technical advance: liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human disease Risk of immunodeficiency virus infection may increase with vaccine-induced immune response.CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections.Effect of early anti-retroviral therapy on the pathogenic changes in mucosal tissues of SIV infected rhesus macaques.Macrophages sustain HIV replication in vivo independently of T cells Immunogenicity of a vaccine regimen composed of simian immunodeficiency virus DNA, rMVA, and viral particles administered to female rhesus macaques via four different mucosal routes Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys.Mucosal immunology of HIV infection.Animal models to achieve an HIV cure Immunology of pediatric HIV infection CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo.

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P2860

Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

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2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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Bing Li

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P2860

Immunological and virological analyses of persons infected by human immunodeficiency virus type 1 while participating in trials of recombinant gp120 subunit vaccines.

A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo

Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia

Phenotypic analysis of antigen-specific T lymphocytes

Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans

Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys

Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

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10.1172/JCI46023

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11

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Sarah J. Ratcliffe

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2011-10-17T00:00:00Z

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