Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics. - Test2 - elhamkhani - TriplyDB

Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.

Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.

http://www.wikidata.org/entity/Q35503280

about

Diseases associated with leaky hemichannels Connexin hemichannel and pannexin channel electrophysiology: how do they differ?Motifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensing Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43.Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.Voltage regulation of connexin channel conductance.Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32 Molecular dynamics simulations of the Cx26 hemichannel: insights into voltage-dependent loop-gating Voltage-dependent conformational changes in connexin channels Connexinopathies: a structural and functional glimpse Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function Accessing gap-junction channel structure-function relationships through molecular modeling and simulations Computational Studies of Molecular Permeation through Connexin26 Channels.Voltage-dependent gating of the Cx32*43E1 hemichannel: conformational changes at the channel entrances.Functional requirement for a highly conserved charged residue at position 75 in the gap junction protein connexin 32.Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46.Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y).Exploring the Membrane Potential of Simple Dual-Membrane Systems as Models for Gap-Junction Channels.The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates.The carboxyl terminal residues 220-283 are not required for voltage gating of a chimeric connexin32 hemichannel.Mechanism of gating by calcium in connexin hemichannels Connexin channel modulators and their mechanisms of action.Extracellular domains play different roles in gap junction formation and docking compatibility.Structure and closure of connexin gap junction channels.Role of gamma carboxylated Glu47 in connexin 26 hemichannel regulation by extracellular Ca²⁺: insight from a local quantum chemistry study.Specificity of the connexin W3/4 locus for functional gap junction formation.Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus A structural and functional comparison of gap junction channels composed of connexins and innexins Gap junction structure: unraveled, but not fully revealed.The 3.5 ångström X-ray structure of the human connexin26 gap junction channel is unlikely that of a fully open channel.Structural studies of N-terminal mutants of connexin 32 using (1)H NMR spectroscopy.Characterization of a novel water pocket inside the human Cx26 hemichannel structure.Modulation of Asymmetric Flux in Heterotypic Gap Junctions by Pore Shape, Particle Size and Charge.On Biophysical Properties and Sensitivity to Gap Junction Blockers of Connexin 39 Hemichannels Expressed in HeLa Cells.Structural studies of N-terminal mutants of Connexin 26 and Connexin 32 using (1)H NMR spectroscopy.Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins.Role of amino terminus in voltage gating and junctional rectification of Shaking B innexins.Structure of an innexin gap junction channel and cryo-EM sample preparation.Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness.The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels.

P2860

Q26797404-D4B34840-44E9-4802-B6B3-18F9163DACF0 Q26824824-DD9D3316-50AE-4A4E-B1BF-92B98873D48F Q26865742-192FD169-2F48-43C1-9FC1-B1F29049D49B Q27320878-4C5C892D-86F1-41BD-9471-4A523768DE04 Q30401716-82DA674C-88A5-40F2-96D5-36E1DA2D64A6 Q34774075-6CD1C899-82B7-4DE9-B70C-20AEDB69571C Q35837081-F0BB0183-F409-4E6D-9898-D31870222B9F Q35843823-4C7971BA-4DA0-41CD-AEDA-77069008D3A1 Q36007904-BE15D0C4-3D1B-4E44-B080-CD282B37FD50 Q36031035-D6591001-8850-401D-894B-0D4EBB0577D2 Q36202777-69E9674E-913E-496B-A827-EEC7088C2F3A Q36260709-B867B3FE-1D01-4E4A-8BBF-92E74F8E37EA Q36552694-C5C61321-F6F6-49F2-BCB0-CA1C5FC06039 Q36568481-1F6B420A-27A6-445C-926D-4782D225B678 Q36579629-3448E11F-D5B1-4BD6-91D7-5DE08424F4E2 Q36836123-69F193F4-416A-4F27-9B21-72DEB613E0FF Q36951964-4DDB93D1-F45D-4256-ABF6-AAFB68E49737 Q37034730-9F5E4627-7162-4004-B429-1813E0E79B82 Q37075368-7C97EE48-006C-4A6D-9F27-7C23E43F53E2 Q37204358-F2F4C760-37F9-4DDB-97CC-38244904BA6A Q37493164-751914C5-BEC4-4A25-9B88-609DD663D545 Q38099907-B3E21312-7D3A-4C4F-9C57-3C88BE2D608F Q38179504-1D15AF02-D96C-4FBA-A1D2-C6A6E1FC0A02 Q38184784-764E0B39-F832-492A-BE6F-7BB343E1C75A Q38552774-742A30E5-C43B-4504-A5C6-B5CAAD9C5EC4 Q38764348-7B951661-F145-4F68-A2A3-92DD1F321E63 Q38805573-DE98DAE7-9260-4746-B08A-4C40559B8BC1 Q38942940-16BFA433-D85A-49C5-8683-F07A86FB5DC7 Q39321400-B5CD199B-4C51-454A-A8A4-D3AAAC0F8641 Q41055040-3BF81A94-3813-4688-850B-4F3F1672BCC4 Q41892577-06ECA7A9-BCB5-4D1E-BB50-7AD75EAAFF78 Q42183057-279BAD3B-6126-4E50-996D-8DA8CAA77065 Q42292699-FE3A448F-0D72-4EB6-B8EE-7DDFD36A31E0 Q42323019-FE6048E5-22E3-46F7-9B72-DDFC342D56A2 Q42387224-40B8F514-B61D-49F6-96F9-CC307E52403B Q42408378-6DBD9D4B-677D-488C-B7F0-17230438E00B Q48611494-A423225B-419C-4B5C-97B7-9CEBB4FD8509 Q50074619-C4F254C2-6906-4444-A1CE-539C243AA320 Q50317223-17507C5F-11CD-42A8-A9F5-6D606F7A3BA4 Q52593258-35A79C30-4E78-45D0-8FD7-5FA0E74F6332

P2860

Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.

http://www.wikidata.org/entity/Q35503280

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Molecular dynamics simulations ...... models with Brownian dynamics.

@ast

Molecular dynamics simulations ...... models with Brownian dynamics.

@en

type

label

Molecular dynamics simulations ...... models with Brownian dynamics.

@ast

Molecular dynamics simulations ...... models with Brownian dynamics.

@en

prefLabel

Molecular dynamics simulations ...... models with Brownian dynamics.

@ast

Molecular dynamics simulations ...... models with Brownian dynamics.

@en

P1433

Q35503280-925902E0-9AC0-4164-A22A-0953ED13111D

P1476

Q35503280-C3E6BBE5-F52C-49B1-90F7-09C072099B7D

P2093

Q35503280-01BCB6B3-33E3-4703-A520-25E4E0251D8F

Q35503280-0883A7B2-D19E-4575-838E-818138A9F673

Q35503280-B862145C-0CBD-48A7-9326-DF14C8612C5B

Q35503280-EC81A6E7-9F63-4F9F-B87F-480A0A5DE8A4

P2860

Q35503280-02C49A52-FDAF-4DB9-847A-067768B0B188

Q35503280-07C5D953-742D-4F6D-98CF-857E75F1B86B

Q35503280-083C48AB-FCE6-4D49-A533-E750A9384E22

Q35503280-0A891481-2C99-4EDA-9EDD-AF9CA7CDA9B7

Q35503280-0B056741-10C5-4029-AD8F-000F0CD403D0

Q35503280-1855413E-4147-4E42-9650-ABCEA07E10EE

Q35503280-1C253CFB-D940-47F4-B7D5-4DC9EED53B47

Q35503280-1FC40AD2-C7CD-4919-AD2D-6E23EB7ADBB2

Q35503280-2649EB27-A95B-4E59-97B0-F1CA6E1BEA78

Q35503280-2BA7F1DD-F658-4B53-A256-DC18B1259DF5

P304

Q35503280-946305EC-3641-4922-9F00-C3131CD1848E

P31

Q35503280-B3DE355B-FC9C-4B7F-A34F-85F41AB58D9A

P356

Q35503280-FB3B2B72-01B4-437B-AE4C-03406F71EB18

P433

Q35503280-0C8B0A71-D3CE-49AE-9E6B-8B8DC5B8794F

P478

Q35503280-B2A0E517-42E7-4439-9E05-DB563A925FD0

P577

Q35503280-E346C421-0EC5-4332-A2BD-552F529EB4C6

P5875

Q35503280-2A31758A-9FA9-40B4-9ED5-B8DFDBCFC3E3

P698

Q35503280-55DE77B4-9F7E-48AC-9F8A-43113059C100

P932

Q35503280-DF24D0C9-808D-4E65-81F7-3412014D66D9

P356

P1433

The Journal of General Physiology

P1476

Molecular dynamics simulations ...... models with Brownian dynamics.

@en

P2093

Andrew L Harris

http://www.w3.org/2001/XMLSchema#string

Angelo Rossi

http://www.w3.org/2001/XMLSchema#string

Taekyung Kwon

http://www.w3.org/2001/XMLSchema#string

Thaddeus A Bargiello

http://www.w3.org/2001/XMLSchema#string

P2860

Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice

Composition and biological significance of the human Nα-terminal acetyltransferases

Canonical dynamics: Equilibrium phase-space distributions

Lysine acetylation: codified crosstalk with other posttranslational modifications

CHARMM: the biomolecular simulation program

Very fast prediction and rationalization of pKa values for protein-ligand complexes

Structure of the connexin 26 gap junction channel at 3.5 A resolution

All-atom empirical potential for molecular modeling and dynamics studies of proteins

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Scalable molecular dynamics with NAMD

P304

475-493

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1085/JGP.201110679

http://www.w3.org/2001/XMLSchema#string

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

138

http://www.w3.org/2001/XMLSchema#string

P577

2011-10-17T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51721411

http://www.w3.org/2001/XMLSchema#string

P698

22006989

http://www.w3.org/2001/XMLSchema#string

P932

3206306

http://www.w3.org/2001/XMLSchema#string