Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation
about
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2AGeneration of a large library of point mutations in polyoma middle T antigen.Catalytically inactive protein phosphatase 2A can bind to polyomavirus middle tumor antigen and support complex formation with pp60(c-src).Cotransfection of granulosa cells with simian virus 40 and Ha-RAS oncogene generates stable lines capable of induced steroidogenesis.Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.Activation of CREB/ATF sites by polyomavirus large T antigen.Cooperation of middle and small T antigens of polyomavirus in transformation of established fibroblast and epithelial-like cell lines.The in vitro behavior of hemopoietic cells transformed by polyoma middle T antigen parallels that of primary human myeloid leukemic cells.Transformation by hamster polyomavirus: identification and functional analysis of the early genes.A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.The polyoma virus T antigen interferes with interferon-inducible gene expression.Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.fos protooncogene and the regulation of gene expression in adipocyte differentiationStructural requirements for pairing of alpha and beta chains in HLA-DR and HLA-DP molecules.Activation of the simian virus 40 (SV40) genome abrogates sensitivity to AVP in a rabbit collecting tubule cell line by repressing membrane expression of AVP receptors.Targeted expression of a conditional oncogene in hematopoietic cells of transgenic mice.Regulatory circuits controlling white versus brown adipocyte differentiation.Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.Polyomavirus middle tumor antigen increases responsiveness to growth factors.Polyomavirus middle T-antigen NPTY mutants.Polyomavirus transforms rat F111 and mouse NIH 3T3 cells by different mechanismsA completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activitySeparation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways.Isolation of vascular smooth muscle cell cultures with altered responsiveness to the antiproliferative effect of heparin.Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cellsTranscriptional regulation of early-response genes during polyomavirus infection.Oncogenes result in genomic alterations that activate a transcriptionally silent, dominantly selectable reporter gene (neo).Inhibition of simian virus 40 T-antigen expression by cellular differentiation.The cellular proteins which can associate specifically with polyomavirus middle T antigen in human 293 cells include the major human 70-kilodalton heat shock proteins.Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody productionRecombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro.Failure of simian virus 40 small t antigen to disorganize actin cables in nonpermissive cell linesCellular proteins that associate with the middle and small T antigens of polyomavirus.Phosphorylation of polyomavirus large T antigen: effects of viral mutations and cell growth state.Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens.Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.
P2860
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P2860
Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Recombinant retroviruses that ...... on growth and differentiation
@ast
Recombinant retroviruses that ...... on growth and differentiation
@en
type
label
Recombinant retroviruses that ...... on growth and differentiation
@ast
Recombinant retroviruses that ...... on growth and differentiation
@en
prefLabel
Recombinant retroviruses that ...... on growth and differentiation
@ast
Recombinant retroviruses that ...... on growth and differentiation
@en
P2093
P2860
P356
P1476
Recombinant retroviruses that ...... on growth and differentiation
@en
P2093
B M Spiegelman
T M Roberts
V Cherington
P2860
P304
P356
10.1073/PNAS.83.12.4307
P407
P577
1986-06-01T00:00:00Z