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The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2HDM2-binding partners: interaction with translation elongation factor EF1alpha.MDM2 regulates dihydrofolate reductase activity through monoubiquitinationTumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signalingTranscription factor TAFII250 promotes Mdm2-dependent turnover of p53Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapyThe p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells.Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication.The antagonism between MCT-1 and p53 affects the tumorigenic outcomes.Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradationSuppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinomap53 and MDM2 are involved in the regulation of osteocalcin gene expression.The alternative translated MDMX(p60) isoform regulates MDM2 activity.Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle.Splicing up mdm2 for cancer proteome diversity.MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice.Vitamin D directly regulates Mdm2 gene expression in osteoblasts.Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells.Therapeutic targets in the ARF tumor suppressor pathway.MDM2 is a novel E3 ligase for HIV-1 Vif.The Zn-finger domain of MdmX suppresses cancer progression by promoting genome stability in p53-mutant cells.p53 -Dependent and -Independent Nucleolar Stress Responses.p53-independent effects of Mdm2.Abl interconnects oncogenic Met and p53 core pathways in cancer cells.HIV-1 Tat potently stabilises Mdm2 and enhances viral replication.Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway.MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability.Ribosomal protein S7 is both a regulator and a substrate of MDM2MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells.Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.Mdm2 promotes genetic instability and transformation independent of p53.Solution structure of the C4 zinc finger domain of HDM2.Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivoRoles of alternative splicing in modulating transcriptional regulation
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
p53-independent functions of MDM2.
@ast
p53-independent functions of MDM2.
@en
type
label
p53-independent functions of MDM2.
@ast
p53-independent functions of MDM2.
@en
prefLabel
p53-independent functions of MDM2.
@ast
p53-independent functions of MDM2.
@en
P1476
p53-independent functions of MDM2
@en
P2093
Gitali Ganguli
P304
P577
2003-12-01T00:00:00Z