Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.
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Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision MedicineGut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?Value of cerebrospinal fluid α-synuclein species as biomarker in Parkinson's diagnosis and prognosisHolocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effectsOligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's diseaseIncreased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's diseaseImmunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease.Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid PolypeptideReview: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathyProtein misfolding in neurodegenerative diseases: implications and strategies.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Development of Passive Immunotherapies for Synucleinopathies.Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology.Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections.Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression.Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease.Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.Parkinson's Disease: Assay of Phosphorylated α-Synuclein in Skin Biopsy for Early Diagnosis and Association with Melanoma.Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy.Rotenone and elevated extracellular potassium concentration induce cell-specific fibrillation of α-synuclein in axons of cholinergic enteric neurons in the guinea-pig ileum.In vivo models of alpha-synuclein transmission and propagation.Alpha-synuclein oligomers: a new hope.Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice.Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain.Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo studyReduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies
P2860
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P2860
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Generation and characterizatio ...... ies for α-synuclein pathology.
@ast
Generation and characterizatio ...... ies for α-synuclein pathology.
@en
type
label
Generation and characterizatio ...... ies for α-synuclein pathology.
@ast
Generation and characterizatio ...... ies for α-synuclein pathology.
@en
prefLabel
Generation and characterizatio ...... ies for α-synuclein pathology.
@ast
Generation and characterizatio ...... ies for α-synuclein pathology.
@en
P2093
P50
P1476
Generation and characterizatio ...... dies for α-synuclein pathology
@en
P2093
David M A Mann
Esther van Dam
Katerina E Paleologou
Laura Parkkinen
Masashi Takanashi
Mustafa T Ardah
Nishant N Vaikath
Nobutaka Hattori
Omar M A El-Agnaf
Shelley L Forrest
P356
10.1016/J.NBD.2015.04.009
P577
2015-04-30T00:00:00Z