Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
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The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial designβ-elemene effectively suppresses the growth and survival of both platinum-sensitive and -resistant ovarian tumor cellsA phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignanciesp21 in cancer: intricate networks and multiple activities3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cellsTransient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiationAlpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells.The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiaeTopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastasesGenistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cellsSuppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.A novel topoisomerase inhibitor, daurinol, suppresses growth of HCT116 cells with low hematological toxicity compared to etoposide.PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2)/M arrest and apoptosis.Pronounced and extensive microtubule defects in a Saccharomyces cerevisiae DIS3 mutant.Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cellsIncreasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 InteractionsThe impact of S- and G2-checkpoint response on the fidelity of G1-arrest by cisplatin and its comparison to a non-cross-resistant platinum(IV) analogA novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action.Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic responseTesticular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells.Cell context-dependent involvement of ATR in early stages of retroviral replicationTherapeutic potential of investigational CHK-1 inhibitors for the treatment of solid tumors.Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.The antileukaemic cell cycle regulatory activities of swainsonine purified from Metarhizium anisopliae fermentation broth.Role of di-allyl disulfide, a garlic component in NF-κB mediated transient G2-M phase arrest and apoptosis in human leukemic cell-lines.Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs.hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells.Fused Toes Homolog modulates radiation cytotoxicity in uterine cervical cancer cells.Stem cell characteristics of cell sub-populations in cell lines derived from head and neck cancers of Fanconi anemia patients.Growth arrest in ovarian cancer cells by hTERT inhibition short-hairpin RNA targeting human telomerase reverse transcriptase induces immediate growth inhibition but not necessarily induces apoptosis in ovarian cancer cells.Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.Caffeine promotes apoptosis in mitotic spindle checkpoint-arrested cells.Characterization of gene rearrangements leading to activation of MDR-1.Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice.SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage.Implications of cell cycle progression on functional sequence correction by short single-stranded DNA oligonucleotides.
P2860
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P2860
Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
@ast
Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
@en
type
label
Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
@ast
Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
@en
prefLabel
Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
@ast
Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
@en
P356
P1476
Cell cycle checkpoints and their impact on anticancer therapeutic strategies.
@en
P2093
Alan Eastman
P304
P356
10.1002/JCB.10699
P577
2004-02-01T00:00:00Z