Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. - Test2 - elhamkhani - TriplyDB

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.

http://www.wikidata.org/entity/Q35644888

about

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins Dual functions of Insig proteins in cholesterol homeostasis INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases Membrane topology of human insig-1, a protein regulator of lipid synthesis The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi A role for smooth endoplasmic reticulum membrane cholesterol ester in determining the intracellular location and regulation of sterol-regulatory-element-binding protein-2 7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment Endoplasmic reticulum-mediated signalling in cellular microdomains.Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase.Lipid metabolism emerges as a promising target for malignant glioma therapy.Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells.Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs.Identification of novel genes and pathways regulating SREBP transcriptional activity Site-1 protease is required for cartilage development in zebrafish.Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.NPC1L1 and cholesterol transport Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice.Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation.Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis.The mevalonate pathway during acute tubular injury: selected determinants and consequences.

P2860

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P2860

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.

http://www.wikidata.org/entity/Q35644888

description

1999 nî lūn-bûn

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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1999年论文

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1999年论文

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name

Sterols regulate cycling of SR ...... doplasmic reticulum and Golgi.

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Sterols regulate cycling of SR ...... doplasmic reticulum and Golgi.

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type

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Sterols regulate cycling of SR ...... doplasmic reticulum and Golgi.

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prefLabel

Sterols regulate cycling of SR ...... doplasmic reticulum and Golgi.

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Sterols regulate cycling of SR ...... doplasmic reticulum and Golgi.

@en

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PNAS.96.20.11235

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Proceedings of the National Academy of Sciences of the United States of America

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Sterols regulate cycling of SR ...... doplasmic reticulum and Golgi.

@en

P2093

A Nohturfft

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J L Goldstein

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M S Brown

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R A DeBose-Boyd

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S Scheek

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P2860

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II

Assembly of asparagine-linked oligosaccharides

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER

Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

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11235-11240

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96

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1999-09-01T00:00:00Z

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12800532

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10500160

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endoplasmic reticulum

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18017

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