Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer - Test2 - elhamkhani - TriplyDB

Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer

Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer

http://www.wikidata.org/entity/Q35645149

about

Reprogramming of energy metabolism as a driver of aging The "virgin birth", polyploidy, and the origin of cancer Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents Metformin in obesity, cancer and aging: addressing controversies Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.microRNAs and cancer metabolism reprogramming: the paradigm of metformin Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation.Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis Metformin for cancer and aging prevention: is it a time to make the long story short?Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway.One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin Glucose promotes breast cancer aggression and reduces metformin efficacy.Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention.Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.The Intricate Interplay between Mechanisms Underlying Aging and Cancer.Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.Ataxia-telangiectasia mutated (ATM) participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells.Low and high linear energy transfer radiation sensitization of HCC cells by metformin.Metformin is synthetically lethal with glucose withdrawal in cancer cells.Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells.Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells.Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.Health benefits of late-onset metformin treatment every other week in mice.Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α Protein Expression and Inhibits Cancer Cell Viability.Transcriptional remodeling in response to transfer upon carbon-limited or metformin-supplemented media in S. cerevisiae and its effect on chronological life span.X-rays and metformin cause increased urinary excretion of cell-free nuclear and mitochondrial DNA in aged rats.Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7

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Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer

http://www.wikidata.org/entity/Q35645149

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Metformin and the ATM DNA dama ...... oost protection against cancer

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Cristina Oliveras-Ferraros

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Javier A Menendez

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Creative Commons Attribution 2.5 Unported

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An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ

Hallmarks of Cancer: The Next Generation

Feedback between p21 and reactive oxygen production is necessary for cell senescence

IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Senescence of activated stellate cells limits liver fibrosis

Common mechanisms of PIKK regulation

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Begoña Martin-Castillo

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DNA-binding protein

neoplasm proteins

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