Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist
about
Structural basis for agonism and antagonism of hepatocyte growth factorAn allosteric switch for pro-HGF/Met signaling using zymogen activator peptidesEngineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptaseTargeting the HGF/Met signalling pathway in cancer.JAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression?Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6.A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of MetHepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor.Progress of antibody-based inhibitors of the HGF-cMET axis in cancer therapy.Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer.Structural and mechanistic insight into how antibodies inhibit serine proteases.Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist.Expression array analysis of the hepatocyte growth factor invasive program.HGF-MET cascade, a key target for inhibiting cancer metastasis: the impact of NK4 discovery on cancer biology and therapeutics.The conformational switch from the factor X zymogen to protease state mediates exosite expression and prothrombinase assembly.Allosteric peptide activators of pro-hepatocyte growth factor stimulate Met signaling.An engineered dimeric fragment of hepatocyte growth factor is a potent c-MET agonist.Dissociation of c-Met phosphotyrosine sites in human cells in response to mouse hepatocyte growth factor but not human hepatocyte growth factor: the possible roles of different amino acids in different species.Rapid, semi-automated protein terminal characterization using ISDetect.
P2860
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P2860
Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist
description
2007 nî lūn-bûn
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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2007年论文
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2007年论文
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name
Utilizing the activation mecha ...... h factor into a Met antagonist
@ast
Utilizing the activation mecha ...... h factor into a Met antagonist
@en
Utilizing the activation mecha ...... h factor into a Met antagonist
@en-gb
type
label
Utilizing the activation mecha ...... h factor into a Met antagonist
@ast
Utilizing the activation mecha ...... h factor into a Met antagonist
@en
Utilizing the activation mecha ...... h factor into a Met antagonist
@en-gb
prefLabel
Utilizing the activation mecha ...... h factor into a Met antagonist
@ast
Utilizing the activation mecha ...... h factor into a Met antagonist
@en
Utilizing the activation mecha ...... h factor into a Met antagonist
@en-gb
P2093
P2860
P356
P1476
Utilizing the activation mecha ...... h factor into a Met antagonist
@en
P2093
Charles Eigenbrot
Daniel Kirchhofer
Henry R Maun
John Ridgway
Karen L Billeci
Lydia Santell
Michael T Lipari
Paul Moran
Robert A Lazarus
Wendy N Sandoval
P2860
P304
P356
10.1073/PNAS.0700184104
P407
P577
2007-03-19T00:00:00Z