Localization of platelet osteonectin at the internal face of the alpha-granule membranes in platelets and megakaryocytesSpecific involvement of caspases in the differentiation of monocytes into macrophagesMonocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functionsExpression of tal-1 and GATA-binding proteins during human hematopoiesisFLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopeniaRecent advances in understanding myelofibrosis and essential thrombocythemiaHigh molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a.TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).Concise Review: Induced Pluripotent Stem Cells as New Model Systems in OncologyProperties and biological roles of TET proteins during embryogenesis and in hematopoiesisCloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamilyAbsence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndromeOverexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitorsA unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia veraMegakaryocytic and erythrocytic lineages share specific transcription factorsGfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cellsA senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferationTET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesisGeneration and characterisation of Rhd and Rhag null miceHeterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patientsThe SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiationThe transcription factor Srf regulates hematopoietic stem cell adhesionRecurrent V75M mutation within the Wiskott-Aldrich syndrome protein: description of a homozygous female patient.JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome.MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation[Megakaryopoiesis: regulation of platelet production by thrombopoietin].Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0Biosynthesis of major platelet proteins in human blood platelets.Therapy-related leukemia associated with myelofibrosis. Blast cell characterization in six cases.Posttransfusion purpura-like syndrome associated with CD36 (Naka) isoimmunization.A new congenital dysmegakaryopoietic thrombocytopenia (Paris-Trousseau) associated with giant platelet alpha-granules and chromosome 11 deletion at 11q23.Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.[Mpl ligand (thrombopoietin) and platelet regulation]
P50
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P50
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French physician
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French physician
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French physician
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Prantsusmaa arst
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fisikawan asal Perancis
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medic francez
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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William Vainchenker
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