The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics.
about
The new (dis)order in RNA regulationG3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunitsATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.Phase separation in biology; functional organization of a higher orderPhase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillizationAre aberrant phase transitions a driver of cellular aging?RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATPArginine Demethylation of G3BP1 Promotes Stress Granule AssemblyPolar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism.An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function.Coexisting Liquid Phases Underlie Nucleolar Subcompartments.Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.Altered mRNP granule dynamics in FTLD pathogenesis.Coupling between cytoplasmic concentration gradients through local control of protein mobility in the Caenorhabditis elegans zygote.RNA transcription modulates phase transition-driven nuclear body assembly.Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories.Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.Modifiers of solid RNP granules control normal RNP dynamics and mRNA activity in early developmentELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans.CAMELOT: A machine learning approach for coarse-grained simulations of aggregation of block-copolymeric protein sequences.Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity.Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.PGL germ granule assembly protein is a base-specific, single-stranded RNase.The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei.RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ LineSpatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5Distinct stages in stress granule assembly and disassemblybicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring.RNA Controls PolyQ Protein Phase Transitions.Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3An RNA-binding atypical tropomyosin recruits kinesin-1 dynamically to oskar mRNPs.Independent active and thermodynamic processes govern the nucleolus assembly in vivo.Prions and Protein Assemblies that Convey Biological Information in Health and Disease.On the origin of non-membrane-bound organelles, and their physiological function.Compositional Control of Phase-Separated Cellular Bodies.Biophysical characterization of organelle-based RNA/protein liquid phases using microfluidics.A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping.Stress granules at the intersection of autophagy and ALS.Principles and Properties of Stress Granules
P2860
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P2860
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The disordered P granule prote ...... unable viscosity and dynamics.
@ast
The disordered P granule prote ...... unable viscosity and dynamics.
@en
type
label
The disordered P granule prote ...... unable viscosity and dynamics.
@ast
The disordered P granule prote ...... unable viscosity and dynamics.
@en
prefLabel
The disordered P granule prote ...... unable viscosity and dynamics.
@ast
The disordered P granule prote ...... unable viscosity and dynamics.
@en
P2093
P2860
P356
P1476
The disordered P granule prote ...... unable viscosity and dynamics.
@en
P2093
Carlos Chih-Hsiung Chen
Christian R Eckmann
Clifford P Brangwynne
Krzysztof Szczepaniak
Shana Elbaum-Garfinkle
Younghoon Kim
P2860
P304
P356
10.1073/PNAS.1504822112
P407
P577
2015-05-26T00:00:00Z