BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.
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Regulation of mammalian transcription and splicing by Nuclear RNAiOpen access chemical probes for epigenetic targetsDiscovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration AnalysisNrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcriptionBET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy modelsMAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cellsBRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma.C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer.Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth.Targeting Transcription Factors in CancerNSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements.MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription programTranscriptional plasticity promotes primary and acquired resistance to BET inhibition.Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression.Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemiaHaploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms.Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agentsPhospho-BRD4: transcription plasticity and drug targeting.Erythropoiesis provides a BRD's eye view of BET protein function.Myogenic regulatory transcription factors regulate growth in rhabdomyosarcomaN,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells.Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.A Biologist's Field Guide to Multiplexed Quantitative Proteomics.BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire.BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance.Developmental Control of NRAMP1 (SLC11A1) Expression in Professional PhagocytesBromodomain 4: a cellular Swiss army knifeEmerging power of proteomics for delineation of intrinsic tumor subtypes and resistance mechanisms to anti-cancer therapies.MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.
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BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
BET Bromodomain Inhibition Sup ...... ors in Acute Myeloid Leukemia.
@ast
BET Bromodomain Inhibition Sup ...... ors in Acute Myeloid Leukemia.
@en
type
label
BET Bromodomain Inhibition Sup ...... ors in Acute Myeloid Leukemia.
@ast
BET Bromodomain Inhibition Sup ...... ors in Acute Myeloid Leukemia.
@en
prefLabel
BET Bromodomain Inhibition Sup ...... ors in Acute Myeloid Leukemia.
@ast
BET Bromodomain Inhibition Sup ...... ors in Acute Myeloid Leukemia.
@en
P2093
P2860
P1433
P1476
BET Bromodomain Inhibition Sup ...... ors in Acute Myeloid Leukemia.
@en
P2093
Christopher R Vakoc
Darryl J Pappin
Fatih Mercan
Jae-Seok Roe
P2860
P304
P356
10.1016/J.MOLCEL.2015.04.011
P577
2015-05-14T00:00:00Z