Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.
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Evolution of patterning systems and circuit elements for locomotionFrom induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identityIsl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexesHair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss.The Isl1-Lhx3 Complex Promotes Motor Neuron Specification by Activating Transcriptional Pathways that Enhance Its Own Expression and FormationLhx3 and Lhx4 suppress Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons.A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells.Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tubemiR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3.Critical Roles of the LIM Domains of Lhx3 in Recruiting Coactivators to the Motor Neuron-Specifying Isl1-Lhx3 Complex.STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex.Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity.ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons.Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity.A modular gain-of-function approach to generate cortical interneuron subtypes from ES cells.The transcription factors islet and Lim3 combinatorially regulate ion channel gene expressionDirect Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients.Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers.Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation.
P2860
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P2860
Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Fusion protein Isl1-Lhx3 speci ...... sing the interneuron programs.
@ast
Fusion protein Isl1-Lhx3 speci ...... sing the interneuron programs.
@en
type
label
Fusion protein Isl1-Lhx3 speci ...... sing the interneuron programs.
@ast
Fusion protein Isl1-Lhx3 speci ...... sing the interneuron programs.
@en
prefLabel
Fusion protein Isl1-Lhx3 speci ...... sing the interneuron programs.
@ast
Fusion protein Isl1-Lhx3 speci ...... sing the interneuron programs.
@en
P2093
P2860
P356
P1476
Fusion protein Isl1-Lhx3 speci ...... sing the interneuron programs.
@en
P2093
James M Cuvillier
Rongkun Shen
Seunghee Lee
Soo-Kyung Lee
P2860
P304
P356
10.1073/PNAS.1114515109
P407
P577
2012-02-16T00:00:00Z