Malin regulates Wnt signaling pathway through degradation of dishevelled2
about
Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2.The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.Deciphering the role of malin in the lafora progressive myoclonus epilepsyHECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation.Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora diseaseReceptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt SignalingInhibiting glycogen synthesis prevents Lafora disease in a mouse model.Phenotype variations in Lafora progressive myoclonus epilepsy: possible involvement of genetic modifiers?Regulation of Wnt/β-catenin signaling by posttranslational modificationsThe Role of Wnt/β-Catenin Signaling Pathway in Disrupted Hippocampal Neurogenesis of Temporal Lobe Epilepsy: A Potential Therapeutic Target?Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan.Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases.The phosphatase activity of laforin is dispensable to rescue Epm2a-/- mice from Lafora disease.PTG protein depletion rescues malin-deficient Lafora disease in mouse.Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis.SGK1 (glucose transport), dishevelled2 (wnt signaling), LC3/p62 (autophagy) and p53 (apoptosis) proteins are unaltered in Lafora disease.
P2860
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P2860
Malin regulates Wnt signaling pathway through degradation of dishevelled2
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Malin regulates Wnt signaling pathway through degradation of dishevelled2
@ast
Malin regulates Wnt signaling pathway through degradation of dishevelled2
@en
type
label
Malin regulates Wnt signaling pathway through degradation of dishevelled2
@ast
Malin regulates Wnt signaling pathway through degradation of dishevelled2
@en
prefLabel
Malin regulates Wnt signaling pathway through degradation of dishevelled2
@ast
Malin regulates Wnt signaling pathway through degradation of dishevelled2
@en
P2093
P2860
P356
P1476
Malin regulates Wnt signaling pathway through degradation of dishevelled2
@en
P2093
Diptendu Mukherjee
Jaiprakash Sharma
Shalaka Mulherkar
P2860
P304
P356
10.1074/JBC.M111.315135
P407
P50
P577
2012-01-05T00:00:00Z