Malin regulates Wnt signaling pathway through degradation of dishevelled2 - Test2 - elhamkhani - TriplyDB

Malin regulates Wnt signaling pathway through degradation of dishevelled2

Malin regulates Wnt signaling pathway through degradation of dishevelled2

http://www.wikidata.org/entity/Q35838878

about

Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2.The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.Deciphering the role of malin in the lafora progressive myoclonus epilepsy HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation.Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease Receptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt Signaling Inhibiting glycogen synthesis prevents Lafora disease in a mouse model.Phenotype variations in Lafora progressive myoclonus epilepsy: possible involvement of genetic modifiers?Regulation of Wnt/β-catenin signaling by posttranslational modifications The Role of Wnt/β-Catenin Signaling Pathway in Disrupted Hippocampal Neurogenesis of Temporal Lobe Epilepsy: A Potential Therapeutic Target?Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan.Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases.The phosphatase activity of laforin is dispensable to rescue Epm2a-/- mice from Lafora disease.PTG protein depletion rescues malin-deficient Lafora disease in mouse.Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis.SGK1 (glucose transport), dishevelled2 (wnt signaling), LC3/p62 (autophagy) and p53 (apoptosis) proteins are unaltered in Lafora disease.

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P2860

Malin regulates Wnt signaling pathway through degradation of dishevelled2

http://www.wikidata.org/entity/Q35838878

description

2012 nî lūn-bûn

@nan

2012年の論文

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2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Malin regulates Wnt signaling pathway through degradation of dishevelled2

@ast

Malin regulates Wnt signaling pathway through degradation of dishevelled2

@en

type

label

Malin regulates Wnt signaling pathway through degradation of dishevelled2

@ast

Malin regulates Wnt signaling pathway through degradation of dishevelled2

@en

prefLabel

Malin regulates Wnt signaling pathway through degradation of dishevelled2

@ast

Malin regulates Wnt signaling pathway through degradation of dishevelled2

@en

P1433

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P356

JBC.M111.315135

P1433

Journal of Biological Chemistry

P1476

Malin regulates Wnt signaling pathway through degradation of dishevelled2

@en

P2093

Diptendu Mukherjee

http://www.w3.org/2001/XMLSchema#string

Jaiprakash Sharma

http://www.w3.org/2001/XMLSchema#string

Shalaka Mulherkar

http://www.w3.org/2001/XMLSchema#string

P2860

Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes

A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease

Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)

Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin.

Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer

A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

Wnt/beta-catenin signaling in development and disease

The Wnt signaling pathway in development and disease

The ups and downs of Wnt signaling in prevalent neurological disorders

P304

6830-6839

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scholarly article

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10.1074/JBC.M111.315135

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9

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287

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2012-01-05T00:00:00Z

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22223637

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3307269

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