Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
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Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?From Heteroaromatic Acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape AnalysisChemical philanthropy: a path forward for antibiotic discovery?On the origins of three-dimensionality in drug-like molecules.Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives.Suzuki-Miyaura cross-coupling optimization enabled by automated feedback.Palladium-catalysed synthesis of triaryl(heteroaryl)methanes.3D-Lab: a collaborative web-based platform for molecular modeling.Modern advances in heterocyclic chemistry in drug discovery.Recent Advances in Gold-Catalyzed Intermolecular Aryl C-H Functionalization.Modern Synthetic Avenues for the Preparation of Functional Fluorophores.Bioactive Natural Product and Superacid Chemistry for Lead Compound Identification: A Case Study of Selective hCA III and L-Type Ca2+ Current Inhibitors for Hypotensive Agent Discovery.Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to SN1 and SN2 Processes.Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides.Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids.Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal CatalysisAsymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates.Breaking Amides using Nickel Catalysis.Copper(i)-catalyzed sulfonylative Suzuki-Miyaura cross-coupling.1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis.Synthesis of olefins via a Wittig reaction mediated by triphenylarsine.Photoinduced, Copper-Catalyzed Decarboxylative C-N Coupling to Generate Protected Amines: An Alternative to the Curtius Rearrangement.Sequential Ruthenium Catalysis for Olefin Isomerization and Oxidation: Application to the Synthesis of Unusual Amino Acids.Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.Origins of high catalyst loading in copper(i)-catalysed Ullmann-Goldberg C-N coupling reactions.Synthesis of Diarylated 4-Pyridylmethyl Ethers via Palladium-Catalyzed Cross-Coupling Reactions.Atropisomerism in medicinal chemistry: challenges and opportunities.Divergent Reactivity of Thioalkynes in Lewis Acid Catalyzed Annulations with Donor-Acceptor Cyclopropanes.Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction.Electrochemically Enabled, Nickel-Catalyzed Amination.Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation.Pd-PEPPSI: a general Pd-NHC precatalyst for Buchwald-Hartwig cross-coupling of esters and amides (transamidation) under the same reaction conditions.Nickel/Photoredox-Catalyzed Amidation via Alkylsilicates and Isocyanates.Click Chemistry: Novel Applications in Cell Biology and Drug Discovery.Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?CITU: A Peptide and Decarboxylative Coupling Reagent.Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides.One-pot borylation/Suzuki-Miyaura sp2-sp3 cross-coupling.Elucidating the Role of the Boronic Esters in the Suzuki-Miyaura Reaction: Structural, Kinetic, and Computational Investigations.Direct Reductive Amination of Carbonyl Compounds Catalyzed by a Moisture Tolerant Tin(IV) Lewis Acid.
P2860
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P2860
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Analysis of Past and Present S ...... ve All the New Reactions Gone?
@ast
Analysis of Past and Present S ...... ve All the New Reactions Gone?
@en
type
label
Analysis of Past and Present S ...... ve All the New Reactions Gone?
@ast
Analysis of Past and Present S ...... ve All the New Reactions Gone?
@en
prefLabel
Analysis of Past and Present S ...... ve All the New Reactions Gone?
@ast
Analysis of Past and Present S ...... ve All the New Reactions Gone?
@en
P1476
Analysis of Past and Present S ...... ve All the New Reactions Gone?
@en
P2093
Dean G Brown
P304
P356
10.1021/ACS.JMEDCHEM.5B01409
P407
P577
2015-12-01T00:00:00Z