The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice - Test2 - elhamkhani - TriplyDB

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

http://www.wikidata.org/entity/Q35859235

about

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease LSD1: biologic roles and therapeutic targeting.LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.Chromatin looping as a target for altering erythroid gene expression Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease New insights into sickle cell disease: mechanisms and investigational therapies.Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression.TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches.Fetal hemoglobin in sickle cell anemia: The Arab-Indian haplotype and new therapeutic agents.The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).Fetal haemoglobin induction in sickle cell disease.Pharmacological and molecular approaches for the treatment of β-hemoglobin disorders.Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness.A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.Fetal Hemoglobin Induction by Epigenetic Drugs

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The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

http://www.wikidata.org/entity/Q35859235

description

2015 nî lūn-bûn

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name

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The LSD1 inhibitor RN-1 induce ...... pathology in sickle cell mice

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The LSD1 inhibitor RN-1 induce ...... pathology in sickle cell mice

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David Harro

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Donald Lavelle

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Greggory Myers

http://www.w3.org/2001/XMLSchema#string

James Douglas Engel

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Joseph DeSimone

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Kim-Chew Lim

http://www.w3.org/2001/XMLSchema#string

Lihong Shi

http://www.w3.org/2001/XMLSchema#string

Mary Lee

http://www.w3.org/2001/XMLSchema#string

Natee Jearawiriyapaisarn

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Raymond C Trievel

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P2860

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases

Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate

Sickle-cell disease

P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease.

PGC-1 coactivator activity is required for murine erythropoiesis.

The beta-thalassemias.

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

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386-396

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scholarly article

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10.1182/BLOOD-2015-02-626259

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3

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126

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Angela E Rivers

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2015-06-01T00:00:00Z

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26031919

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sickle-cell disease

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4504950

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