Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy. - Test2 - elhamkhani - TriplyDB

Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy.

Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy.

http://www.wikidata.org/entity/Q35874392

about

Androgen receptor on the move: boarding the microtubule expressway to the nucleus The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation.Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer.Microtubules and their role in cellular stress in cancer Microtubule inhibitor-based antibody-drug conjugates for cancer therapy.Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression BRCA1 regulates microtubule dynamics and taxane-induced apoptotic cell signaling.Interphase microtubules: chief casualties in the war on cancer?Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.The role of HIF1α in renal cell carcinoma tumorigenesis.Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing.Mechanisms Regulating Protein Localization.GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1α.Moving beyond vascular endothelial growth factor-targeted therapy in renal cell cancer: latest evidence and therapeutic implications.Modulation of estrogen related receptor alpha activity by the kinesin KIF17.Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy.2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice.A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin.Genome maintenance functions of the INO80 chromatin remodeller.

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P2860

Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy.

http://www.wikidata.org/entity/Q35874392

description

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Microtubules regulate hypoxia- ...... plications for taxane therapy.

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Microtubules regulate hypoxia- ...... plications for taxane therapy.

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Microtubules regulate hypoxia- ...... plications for taxane therapy.

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JBC.M112.345587

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Journal of Biological Chemistry

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Microtubules regulate hypoxia- ...... plications for taxane therapy.

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Aurora O'Brate

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Daniel Escuin

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Maria Thadani-Mulero

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Marisa Carbonaro

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Paraskevi Giannakakou

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P2860

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

Dynactin is required for microtubule anchoring at centrosomes

Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end

Targeting HIF-1 for cancer therapy

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms

Hypoxia induces class III beta-tubulin gene expression by HIF-1alpha binding to its 3' flanking region

Regulators of the cytoplasmic dynein motor

Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution

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11859-11869

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10.1074/JBC.M112.345587

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15

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287

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3320934

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