Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.
about
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerizationDedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development.Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signalingRequirements for innate immune pathways in environmentally induced autoimmunity.Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosisCoincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.IRF5 controls both acute and chronic inflammation.Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus.Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model.The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases.The multifaceted biology of plasmacytoid dendritic cells.Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching.Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality.Interferon regulatory factor 5 and autoimmune lupus.Epigenetics and the IRFs: a complex interplay in the control of immunity and autoimmunity.IRF5 and IRF8 modulate the CAL-1 human plasmacytoid dendritic cell line response following TLR9 ligation.Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in miceCross Talk between Inhibitory Immunoreceptor Tyrosine-Based Activation Motif-Signaling and Toll-Like Receptor Pathways in Macrophages and Dendritic Cells.Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 StrainTLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant?MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction.Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis.B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation.Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.
P2860
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P2860
Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
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2012年论文
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name
Spontaneous mutation of the Do ...... uction and antibody responses.
@ast
Spontaneous mutation of the Do ...... uction and antibody responses.
@en
type
label
Spontaneous mutation of the Do ...... uction and antibody responses.
@ast
Spontaneous mutation of the Do ...... uction and antibody responses.
@en
prefLabel
Spontaneous mutation of the Do ...... uction and antibody responses.
@ast
Spontaneous mutation of the Do ...... uction and antibody responses.
@en
P2093
P2860
P356
P1476
Spontaneous mutation of the Do ...... uction and antibody responses.
@en
P2093
Deepta Bhattacharya
Melissa Swiecki
Whitney E Purtha
P2860
P304
P356
10.1073/PNAS.1118155109
P407
P577
2012-03-19T00:00:00Z