Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.
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MDMA and the “Ecstasy Paradigm”3,4-methylenedioxymethamphetamine (MDMA): current perspectivesLost in translation: preclinical studies on 3,4-methylenedioxymethamphetamine provide information on mechanisms of action, but do not allow accurate prediction of adverse events in humansEffect of MDMA-Induced Axotomy on the Dorsal Raphe Forebrain Tract in Rats: An In Vivo Manganese-Enhanced Magnetic Resonance Imaging StudyNew Insights on Different Response of MDMA-Elicited Serotonin Syndrome to Systemic and Intracranial Administrations in the Rat BrainAge-dependent effects of neonatal methamphetamine exposure on spatial learning.(+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal ratsEcstasy: are animal data consistent between species and can they translate to humans?Catechol-o-methyltransferase and 3,4-({+/-})-methylenedioxymethamphetamine toxicity.Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes.(+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty.3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity.The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine.Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings.The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations."Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.Effects of 3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites on cardiovascular function in conscious rats.The Psychopharmacology of ±3,4 Methylenedioxymethamphetamine and its Role in the Treatment of Posttraumatic Stress Disorder.The effects of stereotype threat on cognitive function in ecstasy users.3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings.Qualitative review of serotonin syndrome, ecstasy (MDMA) and the use of other serotonergic substances: hierarchy of risk.Metabolism and disposition of 3,4-methylenedioxymethamphetamine ("ecstasy") in baboons after oral administration: comparison with humans reveals marked differences.Hydrolysis of 3,4-methylenedioxymethamphetamine (MDMA) metabolite conjugates in human, squirrel monkey, and rat plasma.A developmental comparison of the neurobehavioral effects of ecstasy (MDMA)MDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress.Studies of (±)-3,4-methylenedioxymethamphetamine (MDMA) metabolism and disposition in rats and mice: relationship to neuroprotection and neurotoxicity profileTolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges.Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain.Effects of a short-course MDMA binge on dopamine transporter binding and on levels of dopamine and its metabolites in adult male rats.Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults.Simultaneous liquid chromatographic-electrospray ionization mass spectrometric quantification of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its metabolites 3,4-dihydroxymethamphetamine, 4-hydroxy-3-methoxymethamphetamine and 3,4-methyleneValidated liquid chromatographic-electrospray ionization mass spectrometric assay for simultaneous determination of 3,4-methylenedioxymethamphetamine and its metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and 4-hydroxy-3-meNeurotoxic thioether adducts of 3,4-methylenedioxymethamphetamine identified in human urine after ecstasy ingestion(+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the ratNonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat.Cocaine, metamfetamine, and MDMA abuse: the role and clinical importance of neuroadaptation.Safety and side effects of ayahuasca in humans--an overview focusing on developmental toxicology.Pharmacology should be at the centre of all preclinical and clinical studies on new psychoactive substances (recreational drugs).Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro.
P2860
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P2860
Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.
@ast
Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.
@en
type
label
Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.
@ast
Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.
@en
prefLabel
Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.
@ast
Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.
@en
P1476
Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans
@en
P2093
Magí Farré
P304
P356
10.1016/J.TIPS.2004.08.001
P577
2004-10-01T00:00:00Z