Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
about
Antioxidant c-FLIP inhibits Fas ligand-induced NF-kB activation in a phosphatidylinositol 3-kinase/Akt-dependent mannerLesser-Known Molecules in Ovarian CarcinogenesisThe role of BH3-mimetic drugs in the treatment of pediatric hepatoblastomaCaspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcomacFLIP overexpression in T cells in thymoma-associated myasthenia gravisc-FLIP, a master anti-apoptotic regulatorRole of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosisc-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity.Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma.TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases.Selective TRAIL-triggered apoptosis due to overexpression of TRAIL death receptor 5 (DR5) in P-glycoprotein-bearing multidrug resistant CEM/VBL1000 human leukemia cellsGestational diabetes mellitus alters apoptotic and inflammatory gene expression of trophobasts from human term placentaRoles of c-FLIP in Apoptosis, Necroptosis, and Autophagy.Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.HBx-induced NF-κB signaling in liver cells is potentially mediated by the ternary complex of HBx with p22-FLIP and NEMO.Evidence for two modes of synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia in human colon cancer cells.Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.Apoptotic cell signaling in cancer progression and therapyKnockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells.Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium.4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.Use of in-silico assays to characterize the ADMET profile and identify potential therapeutic targets of fusarochromanone, a novel anti-cancer agentNF-κB Regulation of c-FLIP Promotes TNFα-Mediated RAF Inhibitor Resistance in MelanomaTargeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy.Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma.Combination of TRAIL and actinomycin D liposomes enhances antitumor effect in non-small cell lung cancer.Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL.hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral productionNovel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma.The synergistic apoptotic interaction of Indole-3-Carbinol and Genistein with TRAIL on endometrial cancer cells.Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells.Mechanisms of radiation toxicity in transformed and non-transformed cellsActivation of autophagy flux by metformin downregulates cellular FLICE-like inhibitory protein and enhances TRAIL- induced apoptosis.Resistance to Cell Death and Its Modulation in Cancer Stem Cells.TRAIL combinations: The new 'trail' for cancer therapy (Review).Negative regulation of autophagyMetastatic lymph node 51 and fibroblast-like synoviocyte hyperproliferation in rheumatoid arthritis pathogenesis.FLIP: molecular switch between apoptosis and necroptosis.
P2860
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P2860
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
@ast
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
@en
type
label
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
@ast
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
@en
prefLabel
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
@ast
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
@en
P2093
P2860
P1476
Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.
@en
P2093
Ahmad R Safa
Ching-Huang Wu
Travis W Day
P2860
P356
10.2174/156800908783497087
P577
2008-02-01T00:00:00Z