Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy. - Test2 - elhamkhani - TriplyDB

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

http://www.wikidata.org/entity/Q35915103

about

Antioxidant c-FLIP inhibits Fas ligand-induced NF-kB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner Lesser-Known Molecules in Ovarian Carcinogenesis The role of BH3-mimetic drugs in the treatment of pediatric hepatoblastoma Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma cFLIP overexpression in T cells in thymoma-associated myasthenia gravis c-FLIP, a master anti-apoptotic regulator Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity.Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma.TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases.Selective TRAIL-triggered apoptosis due to overexpression of TRAIL death receptor 5 (DR5) in P-glycoprotein-bearing multidrug resistant CEM/VBL1000 human leukemia cells Gestational diabetes mellitus alters apoptotic and inflammatory gene expression of trophobasts from human term placenta Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy.Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.HBx-induced NF-κB signaling in liver cells is potentially mediated by the ternary complex of HBx with p22-FLIP and NEMO.Evidence for two modes of synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia in human colon cancer cells.Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.Apoptotic cell signaling in cancer progression and therapy Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells.Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium.4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells.Use of in-silico assays to characterize the ADMET profile and identify potential therapeutic targets of fusarochromanone, a novel anti-cancer agent NF-κB Regulation of c-FLIP Promotes TNFα-Mediated RAF Inhibitor Resistance in Melanoma Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy.Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma.Combination of TRAIL and actinomycin D liposomes enhances antitumor effect in non-small cell lung cancer.Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL.hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral production Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma.The synergistic apoptotic interaction of Indole-3-Carbinol and Genistein with TRAIL on endometrial cancer cells.Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells.Mechanisms of radiation toxicity in transformed and non-transformed cells Activation of autophagy flux by metformin downregulates cellular FLICE-like inhibitory protein and enhances TRAIL- induced apoptosis.Resistance to Cell Death and Its Modulation in Cancer Stem Cells.TRAIL combinations: The new 'trail' for cancer therapy (Review).Negative regulation of autophagy Metastatic lymph node 51 and fibroblast-like synoviocyte hyperproliferation in rheumatoid arthritis pathogenesis.FLIP: molecular switch between apoptosis and necroptosis.

P2860

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P2860

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

http://www.wikidata.org/entity/Q35915103

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

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Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

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type

label

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

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Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

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prefLabel

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

@ast

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

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Current Cancer Drug Targets

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Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy.

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P2093

Ahmad R Safa

http://www.w3.org/2001/XMLSchema#string

Ching-Huang Wu

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Travis W Day

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P2860

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Inhibition of death receptor signals by cellular FLIP

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

Caspases: the executioners of apoptosis

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

Activation of the NF-kappaB pathway by caspase 8 and its homologs

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

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37-46

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10.2174/156800908783497087

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1

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4524510

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