Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
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Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulationTamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancerOPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplateletEpigenetic disruption of cell signaling in nasopharyngeal carcinoma.The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors.A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancerFrequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer.Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancerA microRNA contribution to aberrant Ras activation in gastric cancerSilencing of hypoxia-inducible tumor suppressor lysyl oxidase gene by promoter methylation activates carbonic anhydrase IX in nasopharyngeal carcinoma.Methylation determines fibroblast activation and fibrogenesis in the kidney.Oncogenic induction of cellular high CpG methylation by Epstein-Barr virus in malignant epithelial cellsDifferential Regulation of RasGAPs in Cancer.Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activationApigenin induces dermal collagen synthesis via smad2/3 signaling pathway.The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas.Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas.Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance.DACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer.Fibulin 1 is downregulated through promoter hypermethylation in gastric cancerAnnexin A6 is down-regulated through promoter methylation in gastric cancer.Identification of RASAL1 as a major tumor suppressor gene in thyroid cancerProtein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma.DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells.Inhibition and termination of physiological responses by GTPase activating proteins.The role of promoter hypermethylation in fibroblast activation and fibrogenesis.Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.Contribution of genetics and epigenetics to progression of kidney fibrosis.Regulation and function of mitophagy in development and cancer.Epigenetic Alterations in Epstein-Barr Virus-Associated Diseases.DLEC1, a 3p tumor suppressor, represses NF-κB signaling and is methylated in prostate cancer.Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes.New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.RASAL1 influences the proliferation and invasion of gastric cancer cells by regulating the RAS/ERK signaling pathway.Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas.In vivo and in vitro expression of the RASAL1 gene in human gastric adenocarcinoma and its clinicopathological significance.NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma.Unravelling the mechanism of dual-specificity GAPs.
P2860
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P2860
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Epigenetic silencing of a Ca(2 ...... s activation in human cancers.
@ast
Epigenetic silencing of a Ca(2 ...... s activation in human cancers.
@en
type
label
Epigenetic silencing of a Ca(2 ...... s activation in human cancers.
@ast
Epigenetic silencing of a Ca(2 ...... s activation in human cancers.
@en
prefLabel
Epigenetic silencing of a Ca(2 ...... s activation in human cancers.
@ast
Epigenetic silencing of a Ca(2 ...... s activation in human cancers.
@en
P2093
P2860
P50
P356
P1476
Epigenetic silencing of a Ca(2 ...... as activation in human cancers
@en
P2093
Ada H Y Wong
Gopesh Srivastava
Hongchuan Jin
Jianming Ying
Qian Zhang
Sabine Kupzig
Zhong-Ying Shen
P2860
P304
12353-12358
P356
10.1073/PNAS.0700153104
P407
P577
2007-07-18T00:00:00Z