about
The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skinPhenotype and course of Hutchinson-Gilford progeria syndromeCharcot-Marie-Tooth disease and intracellular trafficContinued stabilization of the nuclear higher-order structure of post-mitotic neurons in vivoThe cell biology of agingA dual role for A-type lamins in DNA double-strand break repairMammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cellsLamin A/C and emerin are critical for skeletal muscle satellite cell differentiationA high throughput approach for analysis of cell nuclear deformability at single cell levelA pathway linking oxidative stress and the Ran GTPase system in progeria.Cancer biomarker discovery: the entropic hallmark.The role of Lamin A in cytoskeleton organization in colorectal cancer cells: a proteomic investigation.Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.Nuclear envelope transmembrane proteins (NETs) that are up-regulated during myogenesis.Lamin A/C is a risk biomarker in colorectal cancer.Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.A combined epigenetic and non-genetic approach for reprogramming human somatic cellsInterphase phosphorylation of lamin A.Decreased bone formation and osteopenia in lamin a/c-deficient miceConserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation.Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome.Emerinopathy and laminopathy clinical, pathological and molecular features of muscular dystrophy with nuclear envelopathy in Japan.Prelamin A and lamin A appear to be dispensable in the nuclear lamina.Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.Epigenetic gene silencing in cancer: the DNA hypermethylome.Nucleoplasmic lamins and their interaction partners, LAP2alpha, Rb, and BAF, in transcriptional regulation.Investigating the purpose of prelamin A processingThe many facets of H/ACA ribonucleoproteinsMislocalization of prelamin A Tyr646Phe mutant to the nuclear pore complex in human embryonic kidney 293 cells.Aging and bone loss: new insights for the clinician.Nuclear mechanics in diseaseMechanics of the nucleus.Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells.Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease.Nuclear envelope defects cause stem cell dysfunction in premature-aging miceFrom old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.Role of the nuclear envelope in the pathogenesis of age-related bone loss and osteoporosis.Endothelial nuclear lamina is not required for glucocorticoid receptor nuclear import but does affect receptor-mediated transcription activationChromatin organization in relation to the nuclear periphery.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
A-type lamins: guardians of the soma?
@ast
A-type lamins: guardians of the soma?
@en
type
label
A-type lamins: guardians of the soma?
@ast
A-type lamins: guardians of the soma?
@en
prefLabel
A-type lamins: guardians of the soma?
@ast
A-type lamins: guardians of the soma?
@en
P2860
P356
P1433
P1476
A-type lamins: guardians of the soma?
@en
P2093
Chris J Hutchison
Howard J Worman
P2860
P2888
P304
P356
10.1038/NCB1104-1062
P577
2004-11-01T00:00:00Z