Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
about
Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathwayThe relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.Design and implementation of an FPGA-based timing pulse programmer for pulsed-electron paramagnetic resonance applicationsNeuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β-amyloid through activation of SIRT1/Akt1 pathway.Physical properties of polymorphic yeast prion amyloid fibers.Substantial contribution of the two imidazole rings of the His13-His14 dyad to Cu(II) binding in amyloid-β(1-16) at physiological pH and its significance.Intrinsic determinants of Aβ(12-24) pH-dependent self-assembly revealed by combined computational and experimental studies.Copper(II)-Mediated Self-Assembly of Hairpin Peptides and Templated Synthesis of CuS Nanowires.Nanoprobing of the effect of Cu(2+) cations on misfolding, interaction and aggregation of amyloid β peptide.Early stages of amyloid fibril formation studied by liquid-state NMR: the peptide hormone glucagon.Therapeutics for Alzheimer's disease based on the metal hypothesisThe structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study.Pharmacotherapeutic targets in Alzheimer's diseaseCopper(II)-bis-histidine coordination structure in a fibrillar amyloid β-peptide fragment and model complexes revealed by electron spin echo envelope modulation spectroscopyTrientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease.Peptide membranes in chemical evolution.Context dependence of protein misfolding and structural strains in neurodegenerative diseases.Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease.Computational insights into the development of novel therapeutic strategies for Alzheimer's disease.New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.Regulation of myocyte enhancer factor-2 transcription factors by neurotoxinsMetallostasis and amyloid β-degrading enzymes.The MEF2 family and the brain: from molecules to memory.The role of metal ions in amyloid formation: general principles from model peptides.Peptide self-assembly triggered by metal ions.Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design.Amyloid scaffolds as alternative chlorosomes.Altered microglial copper homeostasis in a mouse model of Alzheimer's diseaseCatalytic diversity in self-propagating peptide assemblies.Inhibition of Aβ42 peptide aggregation by a binuclear ruthenium(II)-platinum(II) complex: Potential for multi-metal organometallics as anti-amyloid agents.Cu(II) mediates kinetically distinct, non-amyloidogenic aggregation of amyloid-beta peptides.Peptides organized as bilayer membranes.Amino acid based dynamic metal-biomolecule frameworks.Acidic pH retards the fibrillization of human Islet Amyloid Polypeptide due to electrostatic repulsion of histidines.Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.Inclusion body myositis in Alzheimer's disease.Tuning One-Dimensional Nanostructures of Bola-Like Peptide Amphiphiles by Varying the Hydrophilic Amino Acids.Understanding the metal mediated assembly and hydrogel formation of a β-hairpin peptide.Heavy metal ion hydrogelation of a self-assembling peptideviacysteinyl chelationRemodeling Cross-β Nanotube Surfaces with Peptide/Lipid Chimeras
P2860
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P2860
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
@ast
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
@en
type
label
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
@ast
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
@en
prefLabel
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
@ast
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
@en
P2093
P2860
P356
P1476
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
@en
P2093
Anil K Mehta
David G Lynn
Jacob E Shokes
James A Simmons
Jeffrey M Canfield
Jijun Dong
Kurt Warncke
Robert A Scott
W Seth Childers
P2860
P304
13313-13318
P356
10.1073/PNAS.0702669104
P407
P577
2007-08-08T00:00:00Z