System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. - Test2 - elhamkhani - TriplyDB

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

http://www.wikidata.org/entity/Q35947378

about

Intracellular targeting with engineered proteins Systematic approaches to identify E3 ligase substrates Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21 Evidence of an Antimicrobial Peptide Signature Encrypted in HECT E3 Ubiquitin Ligases.Insights into links between autophagy and the ubiquitin system from the structure of LC3B bound to the LIR motif from the E3 ligase NEDD4.Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.New Aspects on Bacterial Effectors Targeting Rho GTPases.Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.Ubiquitination and the Regulation of Membrane Proteins.A conformational switch regulates the ubiquitin ligase HUWE1.UbFluor: A Mechanism-Based Probe for HECT E3 Ligases.A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold.Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome.Sculpting ion channel functional expression with engineered ubiquitin ligases.Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch.Drug development: Allosteric inhibitors hit USP7 hard.Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants.Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif.A Tunable Brake for HECT Ubiquitin Ligases.UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.Ubiquitination by HUWE1 in tumorigenesis and beyond

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P2860

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

http://www.wikidata.org/entity/Q35947378

description

2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

@zh-cn

name

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

@ast

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

@en

type

label

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

@ast

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

@en

prefLabel

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

@ast

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

@en

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J.MOLCEL.2016.02.005

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System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

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Anne Doye

http://www.w3.org/2001/XMLSchema#string

Avinash Persaud

http://www.w3.org/2001/XMLSchema#string

Chong Jiang

http://www.w3.org/2001/XMLSchema#string

Daniela Rotin

http://www.w3.org/2001/XMLSchema#string

Jicheng Hu

http://www.w3.org/2001/XMLSchema#string

John R Walker

http://www.w3.org/2001/XMLSchema#string

Junjie Chen

http://www.w3.org/2001/XMLSchema#string

Kevin R Brown

http://www.w3.org/2001/XMLSchema#string

Manjeet Mukherjee

http://www.w3.org/2001/XMLSchema#string

Maria A Sartori

http://www.w3.org/2001/XMLSchema#string

P2860

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1

ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

Quantifying ubiquitin signaling

Targeting cancer with kinase inhibitors

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

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121-136

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scholarly article

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10.1016/J.MOLCEL.2016.02.005

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1

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62

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Emmanuel Lemichez

Jeffrey W. Harper

Hari B Kamadurai

Brenda A Schulman

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2016-03-02T00:00:00Z

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297597943

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26949039

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4988125

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