A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
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Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?The importance of serine metabolism in cancerHigh Expression of PHGDH Predicts Poor Prognosis in Non-Small Cell Lung CancerPhosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer.EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma.One-carbon metabolism in cancer.α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.One-Carbon Metabolism in Health and Disease.Targeting amino acid metabolism for cancer therapy.Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype.Escaping Death: Mitochondrial Redox Homeostasis in Cancer CellsD-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation.Bortezomib resistance in multiple myeloma is associated with increased serine synthesis.Positional stable isotope tracer analysis reveals carbon routes during ammonia metabolism of Aedes aegypti mosquitoes.One carbon, many roads.New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound.The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy.Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice.Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma.Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).Targeting Metabolism for Cancer Therapy.Inhibition of PHGDH Attenuates Bleomycin-induced Pulmonary Fibrosis.A Vinyl Sulfone-Based Fluorogenic Probe Capable of Selective Labeling of PHGDH in Live Mammalian Cells.The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code.Profile of David M. Sabatini.Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis.Cancer metabolism: Addicted to serine.A guide to 13C metabolic flux analysis for the cancer biologist.Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase.Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.Signaling Pathways Regulating Redox Balance in Cancer Metabolism.Computational modeling of methionine cycle-based metabolism and DNA methylation and the implications for anti-cancer drug response prediction.Resistant to Targeted Therapy - Aim for Metabolic Liabilities.Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors.Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer
P2860
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P2860
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
@ast
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
@en
type
label
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
@ast
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
@en
prefLabel
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
@ast
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
@en
P2093
P2860
P50
P356
P1476
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
@en
P2093
Amy Q Wang
Brian P Fiske
Caroline A Lewis
Chieh Min Liu
Elizaveta Freinkman
Ganesha Rai
Haeyoon Chung
Jason M Rohde
Kenneth D Westover
Kyle R Brimacombe
P2507
P2860
P2888
P304
P356
10.1038/NCHEMBIO.2070
P50
P577
2016-04-25T00:00:00Z