Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma

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Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways.Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models.

P2860

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Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma

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2015年の論文

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Inhibition of MEK confers hype ...... model of childhood astrocytoma

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Inhibition of MEK confers hype ...... model of childhood astrocytoma

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Inhibition of MEK confers hype ...... model of childhood astrocytoma

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Inhibition of MEK confers hype ...... model of childhood astrocytoma

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Inhibition of MEK confers hype ...... model of childhood astrocytoma

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Inhibition of MEK confers hype ...... model of childhood astrocytoma

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P2093

Adam Studebaker

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Changxian Shen

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Christopher Chronowski

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Doris A Phelps

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Justin Leasure

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Kathryn Bondra

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Paul D Smith

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Peter J Houghton

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Raushan T Kurmasheva

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Star Seum

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P2860

The 2007 WHO classification of tumours of the central nervous system

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

Subtypes of medulloblastoma have distinct developmental origins

BRAF mutation predicts sensitivity to MEK inhibition

Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases.

In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase

Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.

Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation.

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1768-1774

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scholarly article

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10.1002/PBC.25579

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Maryam Fouladi

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2015-05-15T00:00:00Z

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25981859

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4561855

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Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma

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P2860

P2860

Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma

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