Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism.
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Visualizing phosphodiester-bond hydrolysis by an endonucleaseRecent advances in the elucidation of the mechanisms of action of ribozymesA further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme.Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III.Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozymeCurrent status of ribozymes as gene therapy agents for cancer.Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations.Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNABiologically important reactions catalyzed by RNA molecules.A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate.Coupling of fast and slow modes in the reaction pathway of the minimal hammerhead ribozyme cleavage.Explanation by the double-metal-ion mechanism of catalysis for the differential metal ion effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozyme.Metal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozymeNucleases: diversity of structure, function and mechanism.Structural and Biochemical Properties of Novel Self-Cleaving Ribozymes.Evidence for a hydroxide ion bridging two magnesium ions at the active site of the hammerhead ribozyme.Cross talk between the +73/294 interaction and the cleavage site in RNase P RNA mediated cleavage.Inhibition of HIV-1 replication by an HIV-1 dependent ribozyme expression vector with the Cre/loxP (ON/OFF) system.Mechanistic investigation of the cleavage of phosphodiester catalyzed by a symmetrical oxyimine-based macrocyclic dinuclear zinc complex: a DFT study.
P2860
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P2860
Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Observations on catalysis by h ...... -divalent-metal-ion mechanism.
@ast
Observations on catalysis by h ...... -divalent-metal-ion mechanism.
@en
type
label
Observations on catalysis by h ...... -divalent-metal-ion mechanism.
@ast
Observations on catalysis by h ...... -divalent-metal-ion mechanism.
@en
prefLabel
Observations on catalysis by h ...... -divalent-metal-ion mechanism.
@ast
Observations on catalysis by h ...... -divalent-metal-ion mechanism.
@en
P2860
P356
P1476
Observations on catalysis by h ...... -divalent-metal-ion mechanism.
@en
P2093
B W Pontius
P H von Hippel
P2860
P304
P356
10.1073/PNAS.94.6.2290
P407
P50
P577
1997-03-01T00:00:00Z