Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
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Progranulin, lysosomal regulation and neurodegenerative disease.Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease.Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.Trehalose improves traumatic brain injury-induced cognitive impairment.Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.Alagille syndrome: Genetics and Functional Models.Mining the transcriptome for rare disease therapies: a comparison of the efficiencies of two data mining approaches and a targeted cell-based drug screen.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.Trehalose Activates CRE-Dependent Transcriptional Signaling in HT22 Mouse Hippocampal Neuronal Cells: A Central Role for PKA Without cAMP Elevation
P2860
Q38691811-49AFE3C1-20E9-4CA4-B1EC-50DD0F35FB5AQ38695115-B2043137-A358-4224-A37E-AB47695637BFQ38737027-3D4AAD84-E0D7-4631-9444-8B1891B122F2Q38853352-4AE18797-CFE7-493F-B5E8-43F8732272FEQ41455989-3F25D682-5AD8-421B-99A6-267F134EA823Q41512340-0EDC61CA-C69D-4229-9E5F-34DCA34E9512Q41852404-1C5CFBC6-179A-4638-91D0-39490A4F30B2Q43557976-B6353401-2E67-4F47-836C-4D4CE56C4053Q47107627-8FC1C5D3-45A2-4A49-9314-14C9AB37D06EQ47143486-2B06C8E9-CFEE-41B3-AE72-8683496CB19DQ47623958-822BF491-2A6E-43D5-A30E-A9D8AD482206Q50888307-9445D9E6-C777-405B-9557-C057D69E5FC3Q58580563-A31A2A38-C2A8-40AE-88BB-F23F4C30D000
P2860
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@ast
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@en
type
label
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@ast
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@en
prefLabel
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@ast
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@en
P2093
P2860
P50
P1476
Trehalose upregulates progranu ...... treat frontotemporal dementia.
@en
P2093
Chadwick M Hales
Charles A Easley
Christopher J Holler
Gary J Bassell
Georgia Taylor
Kathryn Hudson
Qiudong Deng
William J Watkins
Zachary T McEachin
P2860
P2888
P356
10.1186/S13024-016-0114-3
P577
2016-06-24T00:00:00Z
P6179
1027280528