Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01
about
Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsMolecular Tweezers Targeting Transthyretin AmyloidosisNeurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish EmbryosAmyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β SpeciesAβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands.Isolation and characterization of antibody fragments selective for toxic oligomeric tauSafety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity.Exploring the influence of EGCG on the β-sheet-rich oligomers of human islet amyloid polypeptide (hIAPP1-37) and identifying its possible binding sites from molecular dynamics simulation.General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers.Investigate the binding of catechins to trypsin using docking and molecular dynamics simulationA molecular tweezer antagonizes seminal amyloids and HIV infection.QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomersToxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β speciesThe "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseNatural product and natural product derived drugs in clinical trials.Inositol transport proteins.Anti-amyloid Aggregation Activity of Natural Compounds: Implications for Alzheimer's Drug Discovery.Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends.Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate.The Effect of (-)-Epigallo-catechin-(3)-gallate on Amyloidogenic Proteins Suggests a Common Mechanism.A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.β-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.Protein charge determination and implications for interactions in cell extracts.Association of Tea Consumption with Risk of Alzheimer's Disease and Anti-Beta-Amyloid Effects of Tea.
P2860
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P2860
Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Comparison of three amyloid as ...... nd the molecular tweezer CLR01
@ast
Comparison of three amyloid as ...... nd the molecular tweezer CLR01
@en
type
label
Comparison of three amyloid as ...... nd the molecular tweezer CLR01
@ast
Comparison of three amyloid as ...... nd the molecular tweezer CLR01
@en
prefLabel
Comparison of three amyloid as ...... nd the molecular tweezer CLR01
@ast
Comparison of three amyloid as ...... nd the molecular tweezer CLR01
@en
P2093
P2860
P356
P1476
Comparison of three amyloid as ...... nd the molecular tweezer CLR01
@en
P2093
Chunyu Wang
Frank-Gerrit Klärner
Panchanan Maiti
Thomas Schrader
Zhenming Du
P2860
P304
P356
10.1021/CN200133X
P577
2012-03-07T00:00:00Z