Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes.
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SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.The microenvironment in myelodysplastic syndromes: niche-mediated disease initiation and progression.Bcl-2 proteins in development, health, and disease of the hematopoietic system.Shwachman-Bodian-Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mRNAsThe thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature.New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes.A novel mouse model provides insights into the neutropenia associated with the ribosomopathy Shwachman-Diamond syndrome.How Ribosomes Translate Cancer.Bone Marrow Micro-Environment in Normal and Deranged Hematopoiesis: Opportunities for Regenerative Medicine and Therapies.
P2860
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P2860
Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes.
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
Deficiency of the ribosome bio ...... age progression in myelocytes.
@ast
Deficiency of the ribosome bio ...... age progression in myelocytes.
@en
type
label
Deficiency of the ribosome bio ...... age progression in myelocytes.
@ast
Deficiency of the ribosome bio ...... age progression in myelocytes.
@en
prefLabel
Deficiency of the ribosome bio ...... age progression in myelocytes.
@ast
Deficiency of the ribosome bio ...... age progression in myelocytes.
@en
P2093
P2860
P1433
P1476
Deficiency of the ribosome bio ...... age progression in myelocytes.
@en
P2093
Eric M J Bindels
Ivo P Touw
Johanna M Rommens
Marc H G P Raaijmakers
Maria N Adisty
Marijke G Valkhof
Mathijs A Sanders
Noemi A Zambetti
Paulina M H Van Strien
Remco M Hoogenboezem
P2860
P304
P356
10.3324/HAEMATOL.2015.131573
P577
2015-07-16T00:00:00Z