Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation.
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Altered expression of stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in cancer: will they become a new battlefield for oncotherapy?Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavageDisruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell deathA global transcriptional view of apoptosis in human T-cell activation.Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survivalApoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.Hypocalcaemia, alcohol drinking and viroimmune responses in ART recipients.Inositol trisphosphate receptor Ca2+ release channels.Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interactionGlucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism.Calcium and cancer: targeting Ca2+ transport.An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasisThe BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptorThe endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family.Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival.The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.Apoptosis and autophagy: decoding calcium signals that mediate life or death.Inositol 1,4,5-trisphosphate receptor subtype-specific regulation of calcium oscillations.Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease.The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond.Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update.Bcl-2 proteins and calcium signaling: complexity beneath the surface.Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263.Modulation of Ca2+ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum-Mitochondrial Interface.Hypoxia-induced vasculogenic mimicry formation via VE-cadherin regulation by Bcl-2.Inhibition and conformational change of SERCA3b induced by Bcl-2.Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.Dexamethasone-induced inositol 1,4,5-trisphosphate receptor elevation in murine lymphoma cells is not required for dexamethasone-mediated calcium elevation and apoptosis.Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signalsGlucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors.Distinct Cellular Calcium Metabolism in Radiation-sensitive RKO Human Colorectal Cancer Cells.Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation.
P2860
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P2860
Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Bcl-2 differentially regulates ...... of T cell receptor activation.
@ast
Bcl-2 differentially regulates ...... of T cell receptor activation.
@en
type
label
Bcl-2 differentially regulates ...... of T cell receptor activation.
@ast
Bcl-2 differentially regulates ...... of T cell receptor activation.
@en
prefLabel
Bcl-2 differentially regulates ...... of T cell receptor activation.
@ast
Bcl-2 differentially regulates ...... of T cell receptor activation.
@en
P2093
P2860
P356
P1476
Bcl-2 differentially regulates ...... of T cell receptor activation.
@en
P2093
Clark W Distelhorst
Karen S McColl
Michael C Davis
P2860
P304
P356
10.1083/JCB.200506189
P407
P577
2006-01-01T00:00:00Z