Recent developments in the chemical biology of epothilones.
about
Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targetsBeyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins.Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathiesNovel microtubule-targeting agents - the epothilones.From nature to the laboratory and into the clinicThe epothilones: new therapeutic agents for castration-resistant prostate cancer.C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.Design and synthesis of C6-C8 bridged epothilone A.Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expressionConstructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.Recent Advances in the Development of Antineoplastic Agents Derived from Natural ProductsAnticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Total synthesis and selective activity of a new class of conformationally restrained epothilonesDesign, synthesis and biological evaluation of bridged epothilone D analogues.The epothilones: how pharmacology relates to clinical utility.A phase II evaluation of ixabepilone in the treatment of recurrent/persistent carcinosarcoma of the uterus, an NRG Oncology/Gynecologic Oncology Group studyPhase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives.Evaluation of the pharmacokinetics of ixabepilone for the treatment of breast cancer.The binding mode of side chain- and C3-modified epothilones to tubulin.Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition.Molecular modeling study on the tubulin-binding modes of epothilone derivatives: Insight into the structural basis for epothilones activity.
P2860
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P2860
Recent developments in the chemical biology of epothilones.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Recent developments in the chemical biology of epothilones.
@ast
Recent developments in the chemical biology of epothilones.
@en
type
label
Recent developments in the chemical biology of epothilones.
@ast
Recent developments in the chemical biology of epothilones.
@en
prefLabel
Recent developments in the chemical biology of epothilones.
@ast
Recent developments in the chemical biology of epothilones.
@en
P356
P1476
Recent developments in the chemical biology of epothilones.
@en
P2093
Karl-Heinz Altmann
P304
P356
10.2174/1381612053764715
P577
2005-01-01T00:00:00Z