Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
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Inside out: the role of nucleocytoplasmic transport in ALS and FTLDPrion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative diseaseMembrane-association of mRNA decapping factors is independent of stress in budding yeast.Phase separation in biology; functional organization of a higher orderAre aberrant phase transitions a driver of cellular aging?RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATPPolar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism.Direct observation of structure and dynamics during phase separation of an elastomeric protein.ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils.RNA stores tau reversibly in complex coacervatesSequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.Mechanistic insights into mammalian stress granule dynamics.TDP-43 and FUS en route from the nucleus to the cytoplasm.The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPLIndependent active and thermodynamic processes govern the nucleolus assembly in vivo.Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping.Stress granules at the intersection of autophagy and ALS.Unusual semi-extractability as a hallmark of nuclear body-associated architectural noncoding RNAs.Droplet organelles?Prion-like propagation as a pathogenic principle in frontotemporal dementia.Protein folding, binding, and droplet formation in cell-like conditions.The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain.Cellular Regulation of Amyloid Formation in Aging and Disease.RNA-binding proteins with prion-like domains in health and disease.To be disordered or not to be disordered: is that still a question for proteins in the cell?Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding.Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progressionIt's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles.Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes.Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets.Biological Spectrum of Amyotrophic Lateral Sclerosis Prions.Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs.Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins.
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P2860
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Residue-by-Residue View of In ...... al Domain of RNA Polymerase II
@ast
Residue-by-Residue View of In ...... al Domain of RNA Polymerase II
@en
type
label
Residue-by-Residue View of In ...... al Domain of RNA Polymerase II
@ast
Residue-by-Residue View of In ...... al Domain of RNA Polymerase II
@en
prefLabel
Residue-by-Residue View of In ...... al Domain of RNA Polymerase II
@ast
Residue-by-Residue View of In ...... al Domain of RNA Polymerase II
@en
P2860
P1433
P1476
Residue-by-Residue View of In ...... al Domain of RNA Polymerase II
@en
P2093
Abigail M Janke
Kathleen A Burke
P2860
P304
P356
10.1016/J.MOLCEL.2015.09.006
P577
2015-10-06T00:00:00Z