Targeted deletion of Sost distal enhancer increases bone formation and bone mass
about
Sclerostin Inhibition in the Management of OsteoporosisFrom disease to treatment: from rare skeletal disorders to treatments for osteoporosisFunctional anatomy of distant-acting mammalian enhancersDevelopments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women.Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenicsHDAC5 controls MEF2C-driven sclerostin expression in osteocytes.A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.SOST Inhibits Prostate Cancer Invasion.Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association StudiesLipoprotein receptor-related protein 6 is required for parathyroid hormone-induced Sost suppression.Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model.Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calciumParathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH.Cancer-Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer.Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?Eukaryotic enhancers: common features, regulation, and participation in diseases.The osteocyte plays multiple roles in bone remodeling and mineral homeostasis.Regulation of bone metabolism by Wnt signals.Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development.Role and mechanism of action of sclerostin in bone.The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone.Analysis of SOST expression using large minigenes reveals the MEF2C binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFβ1 responsiveness.The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact.MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton.A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates.The parathyroid hormone-regulated transcriptome in osteocytes: parallel actions with 1,25-dihydroxyvitamin D3 to oppose gene expression changes during differentiation and to promote mature cell function.Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain.MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia.Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease.SOST/Sclerostin Improves Post Traumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance.Mice with sclerostin gene deletion are resistant to the severe sublesional bone loss induced by spinal cord injury.Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients.Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in Human Bone.Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.Parathyroid Hormone Signaling in Osteocytes
P2860
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P2860
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
@ast
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
@en
type
label
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
@ast
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
@en
prefLabel
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
@ast
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
@en
P2093
P2860
P356
P1476
Targeted deletion of Sost distal enhancer increases bone formation and bone mass
@en
P2093
Gabriela G Loots
Mohammad Shahnazari
Nancy E Lane
Nicole M Collette
Richard M Harland
P2860
P304
14092-14097
P356
10.1073/PNAS.1207188109
P407
P577
2012-08-10T00:00:00Z