Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

Item
http://www.wikidata.org/entity/Q36214515
Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and developmentA novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life.Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeysThe multiple facets of FcRn in immunity.Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms.Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates.Current progress in innovative engineered antibodies.Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeys.Target-independent variable region mediated effects on antibody clearance can be FcRn independent.The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.Nonspecificity in a nonimmune human scFv repertoire.Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries.A role for macromolecular crowding in off-target binding of therapeutic antibodies.Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics.
P2860

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

Item
http://www.wikidata.org/entity/Q36214515
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
@zh-cn
name
Balancing charge in the comple ...... improves the pharmacokinetics
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Balancing charge in the comple ...... improves the pharmacokinetics
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type
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Balancing charge in the comple ...... improves the pharmacokinetics
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Balancing charge in the comple ...... improves the pharmacokinetics
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prefLabel
Balancing charge in the comple ...... improves the pharmacokinetics
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Balancing charge in the comple ...... improves the pharmacokinetics
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Balancing charge in the comple ...... improves the pharmacokinetics
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P2093
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10.1080/19420862.2015.1016696
P433
P478
P577
P698
P932