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Alteration of enzyme specificity by computational loop remodeling and designIdentification of cisplatin-regulated metabolic pathways in pluripotent stem cellsLeflunomide reduces proliferation and induces apoptosis in neuroblastoma cells in vitro and in vivoChronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in MiceUridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis.Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome.Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma.Multifunctional glial support by Semper cells in the Drosophila retinaAssociation of thymidylate synthase gene polymorphisms with stavudine triphosphate intracellular levels and lipodystrophy.Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeastUPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan.Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity.A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase.Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections.Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans.Conformational changes of the HsDHODH N-terminal Microdomain via DEER Spectroscopy.CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancerCombined application of NMR- and GC-MS-based metabonomics yields a superior urinary biomarker panel for bipolar disorder.Dual roles of PKM2 in cancer metabolism.Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.Targeted proteomic approach in prostatic tissue: a panel of potential biomarkers for cancer detection.Absorption and intermediary metabolism of purines and pyrimidines in lactating dairy cows.Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phaseFunctional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo.Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes.Decreased glutamate/glutamine levels may mediate cytidine's efficacy in treating bipolar depression: a longitudinal proton magnetic resonance spectroscopy study.Inactivation/deficiency of DHODH induces cell cycle arrest and programed cell death in melanoma.2,4-Dihydroxypyrimidine is a potential urinary metabolite biomarker for diagnosing bipolar disorder.Exploring the structural features of Aspartate Trans Carbamoylase (TtATCase) from Thermus thermophilus HB8 through in silico approaches: a potential drug target for inborn error of pyrimidine metabolism.Structure-wise discrimination of cytosine, thymine, and uracil by proteins in terms of their nonbonded interactions.The potato tuber mitochondrial proteome.Comparison of human erythrocyte purine nucleotide metabolism and blood purine and pyrimidine degradation product concentrations before and after acute exercise in trained and sedentary subjects.Sources and Fates of Carbamyl Phosphate: A Labile Energy-Rich Molecule with Multiple Facets.Dihydroorotate Dehydrogenase: Knockdown Inhibits Cell Growth and Proliferation via Inducing Cell Cycle ArrestPharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Pyrimidine pathways in health and disease.
@ast
Pyrimidine pathways in health and disease.
@en
type
label
Pyrimidine pathways in health and disease.
@ast
Pyrimidine pathways in health and disease.
@en
prefLabel
Pyrimidine pathways in health and disease.
@ast
Pyrimidine pathways in health and disease.
@en
P2093
P1476
Pyrimidine pathways in health and disease.
@en
P2093
Anthony M Marinaki
Elke Zameitat
H Anne Simmonds
Lynette D Fairbanks
Monika Löffler
P304
P356
10.1016/J.MOLMED.2005.07.003
P577
2005-09-01T00:00:00Z