Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
about
Immune Regulation and Antitumor Effect of TIM-1Blocking monoclonal antibodies of TIM proteins as orchestrators of anti-tumor immune responseTIM-1 signaling is required for maintenance and induction of regulatory B cells.T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic CellsApoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivityT cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinaseTIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunitySuppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells.Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma.TIM-4 expressed on APCs induces T cell expansion and survival.The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injuryMultimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in miceGalectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.HAVCR1 gene haplotypes and infection by different viral hepatitis C virus genotypesTim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.Distinct Trafficking of Cell Surface and Endosomal TIM-1 to the Immune Synapse.Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation.TIM-3: a novel regulatory molecule of alloimmune activation.TIM-1 and TIM-3 proteins in immune regulation.Functional annotation of the T-cell immunoglobulin mucin family in birds.Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression.A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury.TIM-4 is differentially expressed in the distinct subsets of dendritic cells in skin and skin-draining lymph nodes and controls skin Langerhans cell homeostasis.The costimulatory role of TIM molecules.Tim-1-Fc suppresses chronic cardiac allograft rejection and vasculopathy by reducing IL-17 productionTIM-4 is expressed on invariant NKT cells but dispensable for their development and function.T cell Ig and mucin domain proteins and immunity.TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.The emerging role of the TIM molecules in transplantation.Experimental models of B cell tolerance in transplantation.The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.Developments in the field of allergy in 2011 through the eyes of Clinical and Experimental Allergy.
P2860
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P2860
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Differential engagement of Tim ...... pansion and effector function.
@ast
Differential engagement of Tim ...... pansion and effector function.
@en
type
label
Differential engagement of Tim ...... pansion and effector function.
@ast
Differential engagement of Tim ...... pansion and effector function.
@en
prefLabel
Differential engagement of Tim ...... pansion and effector function.
@ast
Differential engagement of Tim ...... pansion and effector function.
@en
P2093
P2860
P356
P1476
Differential engagement of Tim ...... pansion and effector function.
@en
P2093
Ana C Anderson
Cristina Gutierrez
Dale T Umetsu
Eric Jensen
Hideo Yagita
Hisaya Akiba
Jaime Imitola
Mohamed H Sayegh
P2860
P304
P356
10.1084/JEM.20062498
P407
P577
2007-07-02T00:00:00Z