The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
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Effect of acycloguanosine treatment of acute and latent herpes simplex infections in miceDrug combinations for treatment of mice infected with acyclovir-resistant herpes simplex virusPathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivoGenomic sequence of Spodoptera frugiperda Ascovirus 1a, an enveloped, double-stranded DNA insect virus that manipulates apoptosis for viral reproductionDe novo synthesis of VP16 coordinates the exit from HSV latency in vivo.A herpesvirus encoded deubiquitinase is a novel neuroinvasive determinantNeurovirulence determinants of genetically engineered Theiler virusesSusceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovirAttenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation of intracerebral injection in nonhuman primates.Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.Persistence of infectious herpes simplex virus type 2 in the nervous system in mice after antiviral chemotherapyCharacterization of virulent and attenuated strains of pseudorabies virus for thymidine kinase activity, virulence and restriction patterns.Vaccination of mice and swine with a pseudorabies virus mutant lacking thymidine kinase activity.Herpes simplex virus DNA synthesis is not a decisive regulatory event in the initiation of lytic viral protein expression in neurons in vivo during primary infection or reactivation from latency.Construction of an excisable bacterial artificial chromosome containing a full-length infectious clone of herpes simplex virus type 1: viruses reconstituted from the clone exhibit wild-type properties in vitro and in vivo.Murine gammaherpesvirus 68 lacking thymidine kinase shows severe attenuation of lytic cycle replication in vivo but still establishes latencyLymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection.Genetic metamorphosis of herpes simplex virus-1 into a biological therapeutic for human cancer.Comparison of effects of famciclovir and valaciclovir on pathogenesis of herpes simplex virus type 2 in a murine infection modelPartial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells.Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.Experimental investigation of herpes simplex virus latencyResistance of herpesviruses to antiviral drugsClinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir.Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo.Herpes simplex virus-based vectors.The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1.Virulence genes in herpes simplex virus type 1 corneal infection.Pathologic studies and comparison of the virulence of herpes simplex virus type 2 from Okinawa, Japan and Chiang Mai, Thailand.Designing Herpes Viruses as Oncolytics.Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo.Functional and molecular analyses of the avirulent wild-type herpes simplex virus type 1 strain KOS.Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activityPathogenesis of experimental skin infections induced by drug-resistant herpes simplex virus mutants.Herpes simplex virus 1 (HSV-1) for cancer treatment.Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system.Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene.
P2860
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P2860
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
description
1978 nî lūn-bûn
@nan
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
1978年论文
@zh
1978年论文
@zh-cn
name
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
@ast
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
@en
type
label
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
@ast
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
@en
prefLabel
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
@ast
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
@en
P2860
P1476
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
@en
P2093
P2860
P304
P356
10.1017/S0022172400025109
P577
1978-10-01T00:00:00Z