Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
about
Evolutionary Ecology of Prokaryotic Immune MechanismsStructural basis for promiscuous PAM recognition in type I-E Cascade from E. coliCRISPR-Cas: biology, mechanisms and relevanceSpacer-length DNA intermediates are associated with Cas1 in cells undergoing primed CRISPR adaptation.Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity.Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems.Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS.Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNAJust how Lamarckian is CRISPR-Cas immunity: the continuum of evolvability mechanisms.SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cellsHighly efficient primed spacer acquisition from targets destroyed by the Escherichia coli type I-E CRISPR-Cas interfering complexThe CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacersReal-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9.DNA Targeting by a Minimal CRISPR RNA-Guided Cascade.CRISPR-Cas: Adapting to change.Conformational regulation of CRISPR-associated nucleases.Active and adaptive Legionella CRISPR-Cas reveals a recurrent challenge to the pathogen.Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape.High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon.The Influence of Copy-Number of Targeted Extrachromosomal Genetic Elements on the Outcome of CRISPR-Cas Defense.Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR-Cas system.Conformational Control of Cascade Interference and Priming Activities in CRISPR ImmunityCRISPR-Cas adaptive immunity and the three Rs.Memory Upgrade: Insights into Primed Adaptation by CRISPR-Cas Immune Systems.Visualization of phage DNA degradation by a type I CRISPR-Cas system at the single-cell level.Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade.Spacer capture and integration by a type I-F Cas1-Cas2-3 CRISPR adaptation complex.Utilizing Biotinylated Proteins Expressed in Yeast to Visualize DNA-Protein Interactions at the Single-Molecule Level.The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit.Conformational Dynamics of DNA Binding and Cas3 Recruitment by the CRISPR RNA-Guided Cascade Complex.Mobile Genetic Elements and Evolution of CRISPR-Cas Systems: All the Way There and Back.Priming in a permissive type I-C CRISPR-Cas system reveals distinct dynamics of spacer acquisition and loss.Life under the Microscope: Single-Molecule Fluorescence Highlights the RNA World.Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.Determining the Specificity of Cascade Binding, Interference, and Primed Adaptation In Vivo in the Escherichia coli Type I-E CRISPR-Cas System.Cas4-Dependent Prespacer Processing Ensures High-Fidelity Programming of CRISPR Arrays.Primed CRISPR adaptation in Escherichia coli cells does not depend on conformational changes in the Cascade effector complex detected in Vitro.The CRISPR conundrum: evolve and maybe die, or survive and risk stagnation.
P2860
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P2860
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
@ast
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
@en
type
label
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
@ast
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
@en
prefLabel
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
@ast
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
@en
P2093
P2860
P50
P1433
P1476
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
@en
P2093
Bryan Gibb
Chantal K Guegler
Eric C Greene
Myles Marshall
Samuel H Sternberg
Sy Redding
P2860
P304
P356
10.1016/J.CELL.2015.10.003
P407
P577
2015-10-28T00:00:00Z