Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.
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Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acidInvolvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's diseaseEffects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human agingGenetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiencyOxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acidFirst-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergeticsMethamphetamine inhibits the glucose uptake by human neurons and astrocytes: stabilization by acetyl-L-carnitineReduction of brain mitochondrial β-oxidation impairs complex I and V in chronic alcohol intake: the underlying mechanism for neurodegenerationMetabolic profiles of biological aging in American Indians: the Strong Heart Family StudyAcetyl L-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos.Impact of dietary genistein and aging on executive function in rats.Micronutrient deficiencies. A major cause of DNA damage.Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production?Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?Natural antioxidants and hypertension: promise and challenges.Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heartPrevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake.An enthusiasm for metabolism.Mitochondria, aging and longevity--a new perspective.Comparative QSAR: on the toxicology of the phenolic OH moiety.Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction.Ethanol impairs glucose uptake by human astrocytes and neurons: protective effects of acetyl-L-carnitine.Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome.Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites.Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.Role of carnitine in diseaseInhibitory effects of alcohol on glucose transport across the blood-brain barrier leads to neurodegeneration: preventive role of acetyl-L: -carnitineBiological determinants of spontaneous physical activity.Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunctionEstradiol impairs response inhibition in young and middle-aged, but not old rats.Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation.Mitochondrial membrane potential and aging.Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts.Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease.Acetyl-L-carnitine increases mitochondrial protein acetylation in the aged rat heart.Role of cardiolipin alterations in mitochondrial dysfunction and disease.The mitochondrial energy transduction system and the aging process.Effect of carnitine on muscular glutamate uptake and intramuscular glutathione in malignant diseases.
P2860
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P2860
Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Acetyl-L-carnitine fed to old ...... ction and ambulatory activity.
@ast
Acetyl-L-carnitine fed to old ...... ction and ambulatory activity.
@en
type
label
Acetyl-L-carnitine fed to old ...... ction and ambulatory activity.
@ast
Acetyl-L-carnitine fed to old ...... ction and ambulatory activity.
@en
prefLabel
Acetyl-L-carnitine fed to old ...... ction and ambulatory activity.
@ast
Acetyl-L-carnitine fed to old ...... ction and ambulatory activity.
@en
P2093
P2860
P356
P1476
Acetyl-L-carnitine fed to old ...... ction and ambulatory activity.
@en
P2093
J C Bartholomew
J Lykkesfeldt
R T Ingersoll
V Vinarsky
P2860
P304
P356
10.1073/PNAS.95.16.9562
P407
P577
1998-08-01T00:00:00Z