EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
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BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer modelsReplacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responsesFrom Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung CancersDevelopment of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitorsEffect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcomePrimary concomitant EGFR T790M mutation predicted worse prognosis in non-small cell lung cancer patientsHereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutationsAnalysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary reportPredictive Factors for Switched EGFR-TKI Retreatment in Patients with EGFR-Mutant Non-Small Cell Lung Cancer.Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitorGerm-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma.Lung cancer in never smokers: molecular profiles and therapeutic implications.Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer.Racial diversity of actionable mutations in non-small cell lung cancer.Mechanisms of resistance to EGFR TKIs and development of a new generation of drugs in non-small-cell lung cancer.Germline EGFR T790M mutation found in multiple members of a familial cohort.Lung cancer mutations and use of targeted agents in HispanicsGerm-line and somatic presentations of the EGFR T790M mutation in lung cancer.Screening for germline EGFR T790M mutations through lung cancer genotyping.Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domainUnlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer.Genetic and biochemical alterations in non-small cell lung cancer.Family history of lung cancer in never smokers with non-small-cell lung cancer and its association with tumors harboring EGFR mutations.Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers.Mechanisms of resistance to EGFR targeted therapies.Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations.Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond.Concurrent molecular alterations in tumors with germ line epidermal growth factor receptor T790M mutations.Review of erlotinib in the treatment of advanced non-small cell lung cancer.Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer.Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications.Biotinylated probe isolation of targeted gene region improves detection of T790M epidermal growth factor receptor mutation via peptide nucleic acid-enriched real-time PCR.Germline mutations predisposing to non-small cell lung cancer.Advances in EGFR as a Predictive Marker in Lung Adenocarcinoma.Covalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles.Epithelial-mesenchymal transition leads to crizotinib resistance in H2228 lung cancer cells with EML4-ALK translocation.Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation.The genomics of lung adenocarcinoma: opportunities for targeted therapies.Mechanisms of Resistance to Epidermal Growth Factor Receptor Inhibitors and Novel Therapeutic Strategies to Overcome Resistance in NSCLC Patients.A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal.
P2860
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P2860
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
@ast
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
@en
type
label
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
@ast
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
@en
prefLabel
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
@ast
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
@en
P2093
P2860
P50
P1433
P1476
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
@en
P2093
Adi Gazdar
Ann G Schwartz
Avinash Viswanathan
Colette Gaba
Daolong Wang
Diptasri Mandal
Dongmei Jia
Elena Kupert
Gloria M Petersen
Haris Vikis
P2860
P304
P356
10.1158/0008-5472.CAN-07-0217
P407
P577
2007-05-01T00:00:00Z