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Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

http://www.wikidata.org/entity/Q36289433

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Plasmid-mediated quinolone resistance in Enterobacteriaceae: a systematic review with a focus on Mediterranean countries.Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death Mycobacterial Cultures Contain Cell Size and Density Specific Sub-populations of Cells with Significant Differential Susceptibility to Antibiotics, Oxidative and Nitrite Stress Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy.The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets.Antibiotic Susceptibility Testing of the Gram-Negative Bacteria Based on Flow Cytometry Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to Isoniazid In Vivo.Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery.Backtracked and paused transcription initiation intermediate of Escherichia coli RNA polymerase Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa.Indole-Induced Activities of β-Lactamase and Efflux Pump Confer Ampicillin Resistance in Pseudomonas putida KT2440 Production of Superoxide in Bacteria Is Stress- and Cell State-Dependent: A Gating-Optimized Flow Cytometry Method that Minimizes ROS Measurement Artifacts with Fluorescent Dyes.Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii.Antibiotics Disrupt Coordination between Transcriptional and Phenotypic Stress Responses in Pathogenic Bacteria.Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action.Targeting bacterial topoisomerases: how to counter mechanisms of resistance.The Potential of Systems Biology to Discover Antibacterial Mechanisms of Plant Phenolics.Antibacterial activity of curcumin via apoptosis-like response in Escherichia coli.How innate immunity proteins kill bacteria and why they are not prone to resistance.Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections.Global Transcriptional Response to Organic Hydroperoxide and the Role of OhrR in the Control of Virulence Traits in Chromobacterium violaceum.Fast 2D NMR Spectroscopy for In vivo Monitoring of Bacterial Metabolism in Complex Mixtures.The In-Feed Antibiotic Carbadox Induces Phage Gene Transcription in the Swine Gut Microbiome."On demand" redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor.Hyperosmotic Agents and Antibiotics Affect Dissolved Oxygen and pH Concentration Gradients in Staphylococcus aureus Biofilms.Comparative metabolomics revealing Staphylococcus aureus metabolic response to different antibiotics.Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function.Microcystin-LR does not induce alterations to transcriptomic or metabolomic profiles of a model heterotrophic bacterium.Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality.Elucidation of the mechanism behind the potentiating activity of baicalin against Burkholderia cenocepacia biofilms.Real-Time In-Cell Nuclear Magnetic Resonance: Ribosome-Targeted Antibiotics Modulate Quinary Protein Interactions.Antibiotic efficacy-context matters.Oxidation of dCTP contributes to antibiotic lethality in stationary-phase mycobacteria.Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria.Bactericidal peptidoglycan recognition protein induces oxidative stress in Escherichia coli through a block in respiratory chain and increase in central carbon catabolism.The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs.Thiol Starvation induces redox-mediated dysregulation of Escherichia coli biofilm components.Cyclic AMP Regulates Bacterial Persistence through Repression of the Oxidative Stress Response and SOS-Dependent DNA Repair in Uropathogenic Escherichia coli.Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria.

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Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

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2015年學術文章

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Bactericidal Antibiotics Induc ...... s that Lead to Cellular Damage

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Benjamin J Korry

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Caroline B M Porter

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Eric G Schwarz

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Graham C Walker

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James J Collins

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Saloni Jain

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Thomas Ferrante

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P2860

Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

Moving forward with reactive oxygen species involvement in antimicrobial lethality

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

A common mechanism of cellular death induced by bactericidal antibiotics

Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibiotics

Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption

Metabolic regulation of mycobacterial growth and antibiotic sensitivity

TCA cycle-mediated generation of ROS is a key mediator for HeR-MRSA survival under β-lactam antibiotic exposure

Pathways of oxidative damage

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