Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.
about
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptorLow-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretionInducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnantsLow density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteinsMolecular processes that handle -- and mishandle -- dietary lipidsThe biogenesis of chylomicronsA gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegansApolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse.Lipoprotein receptors: new roles for ancient proteins.Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3.Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.Membrane binding sites for plasma lipoproteins on endosomes from rat liverMassive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.Dietary cholesterol and downregulation of cholesterol 7 alpha-hydroxylase and cholesterol absorption in African green monkeys.Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo.Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects.Lipoprotein binding and endosomal itinerary of the low density lipoprotein receptor-related protein in rat liver.Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemiaType 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteinsInitial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.Dependence of metabolic and structural heterogeneity of cholesterol ester-rich very low density lipoproteins on the duration of cholesterol feeding in rabbits.Stimulation of cholesteryl ester synthesis in mouse peritoneal macrophages by cholesterol-rich very low density lipoproteins from the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia.Apolipoprotein B metabolism: tracer kinetics, models, and metabolic studies.Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members.Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits.Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance.Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic miceLDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studiesHepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in miceThe syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro.Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor.The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight.Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits.Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases.News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1.
P2860
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P2860
Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.
description
1982 nî lūn-bûn
@nan
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
@yue
1982年學術文章
@zh
1982年學術文章
@zh-hant
name
Hepatic uptake of chylomicron ...... density lipoprotein receptor.
@ast
Hepatic uptake of chylomicron ...... density lipoprotein receptor.
@en
type
label
Hepatic uptake of chylomicron ...... density lipoprotein receptor.
@ast
Hepatic uptake of chylomicron ...... density lipoprotein receptor.
@en
prefLabel
Hepatic uptake of chylomicron ...... density lipoprotein receptor.
@ast
Hepatic uptake of chylomicron ...... density lipoprotein receptor.
@en
P2093
P2860
P356
P1476
Hepatic uptake of chylomicron ...... density lipoprotein receptor.
@en
P2093
P2860
P304
P356
10.1073/PNAS.79.11.3623
P407
P577
1982-06-01T00:00:00Z