Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a - Test2 - elhamkhani - TriplyDB

Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a

Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a

http://www.wikidata.org/entity/Q36301671

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Out of balance: R-loops in human disease Functional genomics of human brain development and implications for autism spectrum disorders Imprinted silencing is extended over broad chromosomal domains in mouse extra-embryonic lineages The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma Role of Genetics in the Etiology of Autistic Spectrum Disorder: Towards a Hierarchical Diagnostic Strategy.Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders.Genomic imprinting does not reduce the dosage of UBE3A in neurons.Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.Differential regulation of non-protein coding RNAs from Prader-Willi Syndrome locus.The role of genomic imprinting in biology and disease: an expanding view.From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease.Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model Towards a therapy for Angelman syndrome by targeting a long non-coding RNA.Toward a Broader View of Ube3a in a Mouse Model of Angelman Syndrome: Expression in Brain, Spinal Cord, Sciatic Nerve and Glial Cells.Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model.Neurodevelopmental Underpinnings of Angelman Syndrome.Long non-coding RNAs in corticogenesis: deciphering the non-coding code of the brain Non-Coding RNAs at the Gnas and Snrpn-Ube3a Imprinted Gene Loci and Their Involvement in Hereditary Disorders.Long non-coding RNAs display higher natural expression variation than protein-coding genes in healthy humans RNAs of the human chromosome 15q11-q13 imprinted region Regulatory mechanisms of long noncoding RNAs in vertebrate central nervous system development and function Potential therapeutic approaches for Angelman syndrome.Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice.Global assessment of imprinted gene expression in the bovine conceptus by next generation sequencing.R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation.Topoisomerases facilitate transcription of long genes linked to autism Epigenetics, autism spectrum, and neurodevelopmental disorders.Long noncoding RNA ZEB1-AS1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB1 Imprinted expression of UBE3A in non-neuronal cells from a Prader-Willi syndrome patient with an atypical deletion.Allelic specificity of Ube3a expression in the mouse brain during postnatal development.E6AP in the brain: one protein, dual function, multiple diseases.Long non-coding RNA in health and disease.Non-coding RNAs in chromatin disease involving neurological defects Angelman syndrome: review of clinical and molecular aspects.Mutation Update for UBE3A variants in Angelman syndrome.A role for chromatin topology in imprinted domain regulation.

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P2860

Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a

http://www.wikidata.org/entity/Q36301671

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2012 nî lūn-bûn

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2012年學術文章

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2012年學術文章

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Ube3a-ATS is an atypical RNA p ...... e paternal expression of Ube3a

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Ube3a-ATS is an atypical RNA p ...... e paternal expression of Ube3a

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Human Molecular Genetics

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Ube3a-ATS is an atypical RNA p ...... e paternal expression of Ube3a

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P2093

Arthur L Beaudet

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Linyan Meng

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Richard E Person

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P2860

The human aminophospholipid-transporting ATPase gene ATP10C maps adjacent to UBE3A and exhibits similar imprinted expression

Maternal disruption of Ube3a leads to increased expression of Ube3a-ATS in trans.

Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression

Silencing by imprinted noncoding RNAs: is transcription the answer?

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy

Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3.

The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A

A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A

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13

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22493002

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3465693

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